RNDr. Karel Královec, Ph.D. | Fakulta chemicko-technologická

RNDr. Karel Královec, Ph.D.

Kontakty

466 037 755, 466 037 764
karel.kralovec@upce.cz
ORCID ID https://orcid.org/0000-0001-9283-0930

Pracoviště

Fakulta chemicko-technologická
Katedra biologických a biochemických věd (30440)

Odborný asistent
assistant professor
Kopírovat adresu odkazu
Konzultace: -
po předchozí domluvě e-mailem nebo telefonicky.
Předmět (Rok) Role
KBBV/C269 (2019) G - - -
KBBV/C351 (2019) G - - -
KBBV/C407 (2019) - PR - -
KBBV/C426 (2019) - PR - -
KBBV/C427 (2019) G - CV SE
KBBV/C501 (2019) G - - -
KBBV/C501 (2019) - PR - -
KBBV/C535 (2019) G - - -
KBBV/C604 (2019) G - - -
KBBV/C853 (2019) G - - -
FORMA:
ROK VYDÁNÍ: Od - Do
ZDROJ:
HABARTOVA, K. - HAVELEK, R. - SEIFRTOVA, M. - KRÁLOVEC, K. - CAHLIKOVA, L. - CHLEBEK, J. - CERMAKOVA, E. - MAZANKOVA, N. - MARIKOVA, J. - KUNES, J. - NOVAKOVA, L. - REZACOVA, M. Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells Scientific Reports, 2018, vol. 8, no. March, s. "4829-1"-"4829-14". ISSN: 2045-2322.
KOKTAN, J. - KRÁLOVEC, K. - HAVELEK, R. - KULICKOVA, J. - REZANKA, P. - KAMAN, O. Magnetic oxide particles with gold nanoshells: Synthesis, properties and cytotoxic effects Colloids and Surfaces A-Physiochemical and Engineering Aspects, 2017, vol. 520, no. May, s. 922-932. ISSN: 0927-7757.
HAVELEK, R. - MUTHNA, D. - TOMSIK, P. - KRÁLOVEC, K. - SEIFRTOVA, M. - CAHLIKOVA, L. - HOSTALKOVA, A. - SAFRATOVA, M. - PERWEIN, M. - CERMAKOVA, E. - REZACOVA, M. Anticancer potential of Amaryllidaceae alkaloids evaluated by screening with a panel of human cells, real-time cellular analysis and Ehrlich tumor-bearing mice Chemico-biological Interactions, 2017, vol. 275, no. September, s. 121-132. ISSN: 0009-2797.
HAVELEK, R. - SEIFRTOVA, M. - KRÁLOVEC, K. - HABARTOVA, K. - CAHLIKOVA, L. - REZACOVA, M. Chelidonine and Homochelidonine Induce Cell Death through Cell Cycle Checkpoints and MAP Kinase Pathways Natural Product Communications, 2017, vol. 12, no. 9, s. 1419-1430. ISSN: 1934-578X.
PEJCHALOVÁ, M. - HAVELEK, R. - KRÁLOVEC, K. - RŮŽIČKOVÁ, Z. - PEJCHAL, V. Novel derivatives of substituted 6-fluorobenzothiazole diamides: synthesis, antifungal activity and cytotoxicity Medicinal Chemistry Research, 2017, vol. 26, no. 9, s. 1847-1862. ISSN: 1054-2523.
KAMAN, O. - KULICKOVA, J. - MARYSKO, M. - VEVERKA, P. - HERYNEK, V. - HAVELEK, R. - KRÁLOVEC, K. - KUBANIOVA, D. - KOHOUT, J. - DVORAK, P. - JIRAK, Z. Mn-Zn Ferrite Nanoparticles With Silica and Titania Coatings: Synthesis, Transverse Relaxivity, and Cytotoxicity. In IEEE Transactions on Magnetics. New York: IEEE (Institute of Electrical and Electronics Engineers), 2017. s. "5300908-1"-"5300908-8" s.
KAMAN, O. - DĚDOURKOVÁ, T. - KOKTAN, J. - KULIČKOVÁ, J. - MARYŠKO, M. - VEVERKA, P. - HAVELEK, R. - KRÁLOVEC, K. - TURNOVCOVÁ, K. - JENDELOVÁ, P. - SCHROEFEL, A. - SVOBODA, L. Silica-coated manganite and Mn-based ferrite nanoparticles: a comparative study focused on cytotoxicity Journal of Nanoparticle Research, 2016, vol. 18, no. 4, s. "100-1"-"100-18". ISSN: 1388-0764.
HAVELEK, R. - SEIFRTOVA, M. - KRÁLOVEC, K. - KROČOVÁ, E. - TEJKALOVÁ, V. - NOVOTNY, I. - CAHLIKOVA, L. - SAFRATOVA, M. - OPLETAL, L. - BÍLKOVÁ, Z. - VAVROVA, J. - REZACOVA, M. Comparative cytotoxicity of chelidonine and homochelidonine, the dimethoxy analogues isolated from Chelidonium majus L. (Papaveraceae), against human leukemic and lung carcinoma cells Phytomedicine, 2016, vol. 23, no. 3, s. 253-266. ISSN: 0944-7113.
PEJCHAL, V. - ŠTĚPÁNKOVÁ, Š. - PEJCHALOVÁ, M. - KRÁLOVEC, K. - HAVELEK, R. - RŮŽIČKOVÁ, Z. - AJANI, H. - LO, R. - LEPSIK, M. Synthesis, structural characterization, docking, lipophilicity and cytotoxicity of 1-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-3-alkyl carbamates, novel acetylcholinesterase and butyrylcholinesterase pseudo-irreversible inhibitors Bioorganic & Medicinal Chemistry, 2016, vol. 24, no. 7, s. 1560-1572. ISSN: 0968-0896.
HORÁKOVÁ, E. - DRABINA, P. - BROŽ, B. - ŠTĚPÁNKOVÁ, Š. - VORČÁKOVÁ, K. - KRÁLOVEC, K. - HAVELEK, R. - SEDLÁK, M. Synthesis, characterization and in vitro evaluation of substituted N-(2-phenylcyclopropyl)carbamates as acetyl- and butyrylcholinesterase inhibitors Journal of enzyme inhibition and medicinal chemistry, 2016, vol. 31, no. Supp. 3, s. 173-179. ISSN: 1475-6366.
KUČÍRKOVÁ, L. - KRÁLOVEC, K. - HAVELEK, R. - BRŮČKOVÁ, L. - SEDLÁK, M. Toxicita magnetických nanočástic Chemické listy, 2015, vol. 109, no. 9, s. 693-700. ISSN: 0009-2770.
DOSKOČIL, I. - HOŠŤÁLKOVÁ, A. - ŠAFRATOVÁ, M. - BENEŠOVÁ, N. - HAVLÍK, J. - HAVELEK, R. - KUNEŠ, J. - KRÁLOVEC, K. - CHLEBEK, J. - CAHLÍKOVÁ, L. Cytotoxic activities of Amaryllidaceae alkaloids against gastrointestinal cancer cells Phytochemistry Letters, 2015, vol. 13, no. September 2015, s. 394-398. ISSN: 1874-3900.
HAVELEK, R. - ĆMIELOVÁ, J. - KRÁLOVEC, K. - BRŮČKOVÁ, L. - BÍLKOVÁ, Z. - FOUSOVÁ, I. - ŠINKOROVÁ, Z. - VÁVROVÁ, J. - ŘEZÁČOVÁ, M. Specific inhibition of Wee1 kinase and Rad51 recombinase: A strategy to enhance the sensitivity of leukemic T-cells to ionizing radiation-induced DNA double-strand breaks Biochemical and Biophysical Research Communications, 2014, vol. 453, no. 3, s. 569–575. ISSN: 0006-291X.
HAVELEK, R. - SEIFRTOVÁ, M. - KRÁLOVEC, K. - BRŮČKOVÁ, L. - CAHLÍKOVÁ, L. - DALECKÁ, M. - VÁVROVÁ, J. - ŘEZÁČOVÁ, M. - OPLETAL, L. - BÍLKOVÁ, Z. The effect of Amaryllidaceae alkaloids haemanthamine and haemanthidine on cell cycle progression and apoptosis in p53-negative human leukemic Jurkat cells Phytomedicine, 2014, vol. 21, no. 4, s. 479-490. ISSN: 0944-7113.
HAVELEK, R. - ĆMIELOVÁ, J. - KRÁLOVEC, K. - BRŮČKOVÁ, L. - VÁVROVÁ, J. - ŘEZÁČOVÁ, M. - BÍLKOVÁ, Z. Combined Wee1 and Rad51 inhibitor treatment decrease repair of double-strand breaks, survival and alters cells cycle of irradiated T-leukemia cells. In FEBS Journal Vol. 281, s1. Hoboken: Wiley-Blackwell, 2014. s. 714 s.
DALECKÁ, M. - HAVELEK, R. - KRÁLOVEC, K. - BRŮČKOVÁ, L. - CAHLIKOVA, L. Alkaloidy rostlin čeledi Amaryllidaceae jako potenciální léčiva v terapii nádorových onemocnění Chemické listy, 2013, vol. 107, no. 9, s. 701-708. ISSN: 0009-2770.
SEDLÁK, M. - BHOSALE, D. - BENEŠ, L. - PALARČÍK, J. - KALENDOVÁ, A. - KRÁLOVEC, K. - IMRAMOVSKÝ, A. Synthesis and characterization of a pH-sensitive conjugate of isoniazid with Fe3O4@SiO2 magnetic nanoparticles Bioorganic & Medicinal Chemistry Letters, 2013, vol. 23, no. 16, s. 4692-4695. ISSN: 0960-894X.
KRÁLOVEC, K. - ŽÁKOVÁ, P. - MUŽÁKOVÁ, V. Development of the olfactory and vomeronasal organs in Discoglossus pictus (Discoglossidae, Anura) Journal of Morphology, 2013, vol. 274, no. 1, s. 24-34. ISSN: 0362-2525.
IMRAMOVSKÝ, A. - PEJCHAL, V. - ŠTĚPÁNKOVÁ, Š. - VORČÁKOVÁ, K. - JAMPÍLEK, J. - VANČO, J. - ŠIMŮNEK, P. - KRÁLOVEC, K. - BRŮČKOVÁ, L. - MANDÍKOVÁ, J. - TREJTNAR, F. Synthesis and in vitro evaluation of new derivatives of 2-substituted-6-fluorobenzo[d]thiazoles as cholinesterase inhibitors Bioorganic & Medicinal Chemistry, 2013, vol. 21, no. 7, s. 1735-1748. ISSN: 0968-0896.
HORÁK, D. - SVOBODOVÁ, Z. - AUTEBERT, J. - COUDERT, B. - PLICHTA, Z. - KRÁLOVEC, K. - BÍLKOVÁ, Z. - VIOVY, J. Albumin-coated monodisperse magnetic poly(glycidyl methacrylate) microspheres with immobilized antibodies: Application to the capture of epithelial cancer cells Journal of Biomedical Materials Research - Part A, 2013, vol. 101A, no. 1, s. 23-32. ISSN: 1552-4965.
HAVELEK, R. - SEIFRTOVÁ, M. - KRÁLOVEC, K. - BRŮČKOVÁ, L. - CAHLÍKOVÁ, L. - ŘEZÁČOVÁ, M. - BÍLKOVÁ, Z. Effect of Amaryllidaceae alkaloids haemanthamine and haemanthidine on cell viability, apoptosis and cell cycle progression in human T-lymphoblast cell line. In FEBS JOURNAL SUPPLEMENT. New York: Wiley-Blackwell, 2013. s. 322-323 s.
MUŽÁKOVÁ, V. - KANĎÁR, R. - MELOUN, M. - SKALICKÝ, J. - KRÁLOVEC, K. - ŽÁKOVÁ, P. - VOJTÍŠEK, P. Inverse Correlation between Plasma Beta-Carotene and Interleukin-6 in Patients with Advanced Coronary Artery Disease International Journal for Vitamin and Nutrition Research, 2010, vol. 80, no. 6, s. 369-377. ISSN: 0300-9831.
KRÁLOVEC, K. - ROČEK, Z. - ŽÁKOVÁ, P. - MUŽÁKOVÁ, V. Development of the ethmoidal structures of the endocranium in Discoglossus pictus (Anura: Discoglossidae) Journal of Morphology, 2010, vol. 2010, no. 271, s. 1078-1093. ISSN: 0362-2525.
KRÁLOVEC, K. - ROČEK, Z. DEVELOPMENT OF THE ANTERIOR PART OF SKULL IN THE ANURA. In Journal of Morphology. Wiley-Blackwell, 2007. s. 1041 s.
KRÁLOVEC, K. - ROČEK, Z. Structure and development of the ethmoidal part of the skull in Anura, and its ancestral pattern in Temnospondyli Journal of Morphology, 2004, vol. neuveden, no. 260, s. 305. ISSN: 0362-2525.
ČIHÁK, R. - KRÁLOVEC, K. - ROČEK, Z. Developmental Origin of the Frontoparietal Bone in Bombina variegata (Anura: Discoglossidae) Journal of Morphology, 2003, vol. , no. 255, s. 122-129. ISSN: 0362-2525.
PROJEKT PROGRAM POSKYTOVATEL ZAČÁTEK KONEC
The use of modern analytical, molecular biological, microbiological and cytological methods in biological studies Student Grant Competition Univerzita Pardubice 01.01.2018 31.12.2018
Modern analytical, molecular biological, microbiological and cytological methods applicable for clinical purposes Student Grant Competition Univerzita Pardubice 01.01.2017 31.12.2017
The use of analytical, molecular biological, microbiological and cytological methods for analysis of biological samples Student Grant Competition Univerzita Pardubice 01.01.2016 31.12.2016
The use of modern analytical and molecular biological methods for biological samples analysis Student Grant Competition Univerzita Pardubice 01.01.2015 31.12.2015
New methods for the analysis of biological samples Student Grant Competition Univerzita Pardubice 01.01.2014 31.12.2014
Study of property of biological and biochemical systems through "in vitro" methods with focus on medical, farmaceutical, veterinary and nutrient aplications. Student Grant Competition Univerzita Pardubice 01.01.2012 31.12.2012
Rozvoj přístrojového vybavení FChT Univerzity Pardubice 3. Programme for the development of instrumentation, equipment and modern technologies Ministerstvo školství, mládeže a tělovýchovy 01.01.2011 31.12.2011
Inovace laboratoří pro praktickou výuku fyziologie a biologie na Fakultě chemicko-technologické Univerzity Pardubice HEDF - A a) Ministerstvo školství, mládeže a tělovýchovy 01.01.2005 31.12.2005