Publication detail

Low plasma levels of beta-carotene in obese men with advanced coronary artery disease

Year: 2008

Type of publication: článek ve sborníku

Name of source: Free Radical Research

Publisher name: Informa Healthcare UK

Place: London

Page from-to: S110

Titles:

Language	Name	Abstract	Keywords
cze	Nízké hladiny beta-karotenu u obézních osob s ischemickou chorobou srdeční	Nízké hladiny beta-karotenu u obézních osob s ischemickou chorobou srdeční	beta-karoten; ischemická choroba srdeční; oxidační stres
eng	Low plasma levels of beta-carotene in obese men with advanced coronary artery disease	Coronary heart disease (CHD) is the leading cause of morbidity and mortality in developed countries with west-east stratification. Differences in classical risk factors do not account for the variability in the incidence found in different populations. Considerable evidence indicates that oxidants are involved in the development and clinical expression of CHD and that antioxidants may contribute to disease resistance. An important lipid-soluble antioxidant dietary component is a-tocopherol, major chain-breaking antioxidant in body tissues, and b-carotene. Significant regional differences in plasma levels of these compounds were found. The aim of this study has been to determine plasma concentrations of b-carotene and a-tocopherol, the level of systemic inflammation and oxidative stress in patients with advanced coronary artery disease. Oxidative stress parameters were determined in group of patients with advanced coronary artery disease (at least 50% stenosis of the left main coronary artery or 70% stenosis of the epicardial coronary artery according to coronarographic examination; S, n=91) and control group of examined patients with normal coronary arteries (normal coronarographic status; C, n=49). Plasma levels of b-carotene, a-tocopherol and malondialdehyde were determined by HPLC, free radical concentration by direct method based on chlorophyllin acceptance of electrons. Plasma levels of high sensitive C-reactive protein, Interleukine-6 (IL-6), glucose, total cholesterol, triglycerides, HDL-ch, LDL-ch and fibrinogen were followed by standard procedures. In patients with coronary stenosis (S) lower levels of b-carotene (BC) and a-tocopherol (AT) coincided with higher level of inflammation and in lesser extent of free radicals (FR). BC: S: 0.10  0.11 mol/l vs C: 0.14  0.08 mol/l (p0.05); AT: S: 22.59  7.16 mol/l vs C: 23.75  5.95 (p>0.05); IL-6: S: 5.75  3.55 ng/l vs C: 3.92  2.76	Beta-carotene; coronary artery disease; oxidative stress

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