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The Influence of Antioxidant Vitamins on Clinical Manifestation of Reperfusion Injury during Myocardial Infarction
Authors: Mužáková Vladimíra | Kanďár Roman | Meloun Milan | Vojtíšek Petr | Skalický Jiří
Year: 2003
Type of publication: ostatní - přednáška nebo poster
Name of source: Clinical Chemistry and Laboratory Medicine Special Supplement
Publisher name: Walter de Gruyter GmbH & Co. KG
Place: Berlin
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Titles:
Language Name Abstract Keywords
cze Vliv antioxidačních vitamínů na klinickou manifestaci reperfusního poškození během infarktu myokardu antioxidant vitamins;myocardial infarction;reperfusion injury
eng The Influence of Antioxidant Vitamins on Clinical Manifestation of Reperfusion Injury during Myocardial Infarction Background: The pool of antioxidant vitamins is gradually depleted during elimination of reactive oxygen species within reperfusion treatment of acute myocardial infarction (AMI). Aim: Verification of the hypothesis that vitamin shortage contributes to clinical complications of AMI. Methods: Serum levels of vitamin E (VE), beta-carotene (BC) and vitamin C (VC) were determined in 50 patients with the first AMI (diagnosed by clinical, biochemical and electrocardiographic criteria, accepted within 6 h since symptom initiation) before starting of thrombolytic treatment; VE and BC were determined by HPLC, VC by spectrophotometric method. The patients were divided according to the vitamin concentrations (group H VE > 15.6 microM > group L, BC: H > 0.07 microM > L, VC: H > 25 microM > L). These values are the cutting points for the fourth lowest quartile of the studied population. The groups were compared in these parameters: extent of myocardial damage (area under the curves of Troponin I, CK-MB), arrhythmia and congestive heart failure occurrence, size of ejection fraction, positivity of ventricular late potentials. Statistical methods: t-test, non-parametric test of two samples, NCSS2000. Results: No statistical significant differences between the group H and L either for VE, BC or for VC were found. Conclusion: No correlation among serum concentrations of vitamin E, beta-carotene and vitamin C and the extent of myocardial infarction and clinical course of AMI was found. antioxidant vitamins;myocardial infarction;reperfusion injury

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