Publication detail

The Base-Catalysed Cyclisation of Phenyl N-(2-Hydroxybenzyl)-N-methylcarbamates

Authors: Štěrba Vojeslav | Hrabík Oldřích | Kaválek Jaromír | Mindl Jaromír | Williams Andew

Year: 2003

Type of publication: článek v odborném periodiku

Name of source: Organic & Biomolecular Chemistry

Publisher name: Royal Society of Chemistry

Place: Cambridge

Page from-to: 415-421

Titles:

Language	Name	Abstract	Keywords
cze	Bázicky katalyzovaná cyklizace fenyl-N-(2-hydroxybenzyl)-N-methylkarbamátů	Bázicky katalyzovaná cyklizace fenyl-N-(2-hydroxybenzyl)-N-methylkarbamátů	Carbamates, intramolecular reactions, reaction kinetics, reactivity-selectivity relationships
eng	The Base-Catalysed Cyclisation of Phenyl N-(2-Hydroxybenzyl)-N-methylcarbamates	The rate law of the cyclisation of phenyl N-(2-hydroxybenzyl)-N-methylcarbamates in aqueous solution was identified. The values of rate and equilibrium constants fit Brønsted equations against pK´s corresponding free phenols but system does not conform to the reactivity-selectivity hypothesis. Stepwise mechanism involving a tetrahedral intermediate is ruled out, concerted displacement is probable.	Karbamáty, intramolekulární reakce, reakční kinetika, vztah reaktivita-selektivita

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