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Synthesis, Structural Study, In vitro Antitumour and Trypanocidal Activity of Tetrakis(3-methoxypropyl)tin and (3-Methoxypropyl)tin Chlorides
Authors: Lébl Tomáš | Smička Aleš | Brus Jiří | Bruhn Clemens
Year: 2003
Type of publication: článek v odborném periodiku
Name of source: European Journal of Inorganic Chemistry
Publisher name: Wiley-VCH
Place: Weinheim
Page from-to: 143-148
Titles:
Language Name Abstract Keywords
cze Syntéza, strukturální studie, in vitro antitumorová a trypanocidalní aktivita tetrakis(3-methoxypropyl)stananu a 3-methoxypropylstanyl chloridů Syntéza, strukturální studie, in vitro antitumorová a trypanocidalní aktivita tetrakis(3-methoxypropyl)stananu a 3-methoxypropylstanyl chloridů Cín, Cheláty, O ligandy, Objasnění struktury, Výzkum léků
eng Synthesis, Structural Study, In vitro Antitumour and Trypanocidal Activity of Tetrakis(3-methoxypropyl)tin and (3-Methoxypropyl)tin Chlorides The set of four water-soluble (3-methoxypropyl)stannanes with the general formula (CH3OCH2CH2CH2)xSnCl4-x where x = 4 (1), x = 3 (2), x = 2 (3) and x = 1 (4), was prepared. For 3 and 4, which were isolated in crystalline state, it was shown by X ray diffraction that the tin atom is coordinated in distorted octahedral and trigonal-bipyramidal geometry, respectively, i.e. in both cases, the oxygen atoms of 3-methoxypropyl groups were coordinated to the central tin atom forming chelates. For all compounds, structures in CDCl3 and DMSO-d6 solutions were proposed from 13C and 119Sn NMR spectra. In CDCl3 solutions, the degree of donor-acceptor bonding between the central tin atom and oxygen atom of 3 methoxypropyl substituent was evaluated on the basis of 17O NMR chemical shifts and 3,6J(1H,119Sn) long-range coupling constants. Compounds 2 and 3 exhibited promising in vitro antitumour and trypanocidal activity. Tin;Chelates;O ligands;Structure elucidation;Drug research

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