Login for students

Login for employees

Publication detail

The diminishing of oxidative stress by diet optimization may reduce the occurrence of metabolic syndrome in obese persons.
Authors: Mužáková Vladimíra | Skalický Jiří | Kanďár Roman | Meloun Milan | Kovařík Jakub | Roušar Tomáš
Year: 2007
Type of publication: článek ve sborníku
Name of source: Clinical Chemistry and Laboratory Medicine Special Supplement
Publisher name: Walter de Gruyter GmbH & Co. KG
Place: Berlin
Page from-to: S152
Titles:
Language Name Abstract Keywords
cze Snížení oxidačního stresu optimalizací diety může snižovat výskyt metabolického syndromu u obézních osob Snížení oxidačního stresu optimalizací diety může snižovat výskyt metabolického syndromu u obézních osob metabolický syndrom; oxidační stres; snížení energetického příjmu
eng The diminishing of oxidative stress by diet optimization may reduce the occurrence of metabolic syndrome in obese persons. Background. Metabolic syndrome (MS), associated with high cardiovascular morbidity and mortality, has increasing impact. The aim of our study was to evaluate the influence of diet optimization on oxidative stress and MS occurrence in obese patients. Methods. Oxidative stress markers (total amount of free radicals, malondialdehyde, allantoin, a-1antiproteinase, GSSG/GSH ratio), total antioxidant capacity and lipid standardised a-tocopherol were determined in obese patients with restricted energy intake with lowering dietary carbohydrates (A; n=15) and those with the same grade of obesity but not following dietary recommendations (B; n=17) and in 48 healthy controls. In patients we evaluated presence of MS according to NCEP ATPIII. Free radical concentration was determined by direct method based on chlorophyllin acceptance of electrons, total antioxidant capacity using kit TAS (Randox, UK), malondialdehyde and a-tocopherol by HPLC. Plasma levels of glucose, triglycerides, HDL-ch, LDL-ch, fibrinogen, uric acid, BMI and waistline were followed. Results. Group A exhibited lower oxidative stress markers - free radicals (A: 5.18+-1.68 mmol/l vs B: 8.43+-3.66 mmol/l, p<0.01), GSSG/GSH ratio (A: 11.74+-5.01 % vs B: 15.38+-5.93 %, p<0.05) and higher antioxidants: lipid standardised a-tocopherol (A: 3.70+-0.51 umol/l vs B: 3.35+-0.60, p<0.05) and ceruloplasmin. Conclusion. Energy intake restriction by 2 000 kJ, mainly due to carbohydrate limitations, decreased oxidative stress and simultaneously increased lipid-standardised a-tocopherol and ceruloplasmin in obese people. These changes correlated with diminished MS occurrence by about 50 %, even when weight loss did not occur. metabolic syndrome; oxidative stress; energy intake restriction

Departments

Other Parts

Map

en.mapy.cz

Services

Popular Links

© 2023 University of Pardubice, Studentská 95, 532 10 Pardubice 2
Phone: +420 466 036 111, 466 036 112, 466 036 113
Webmaster, RSS
Data box ID: f5vj9hu
Accessibility Statement
CC BY-NC-ND 4.0