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Ring-substituted Vanadocene(IV) Compounds

Authors: Honzíček Jan | Vinklárek Jaromír | Klepalová Iva | Frumarová Božena | Hrbáč Jan

Year: 2009

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
cze	Vanodocenové komplexy substituované na cyklopentadienylových kruzích	Methoxy-substituovane vanadoceny ((C5H4R)2VCl2 (7: R = 2-CH2C6H4OMe, 8: R = 4-CH2C6H4OMe, 9: R = CH2CH2OMe) byly pripraveny podle postupu, který byl dříve použit pro přípravu ansa-vanadocenových komplexů. tyto sloučeniny byly charakterizovány pomocí spektroskopických metod. Struktura komplexů 7 a 9 byla určena pomocí rentgenostrukturní analýzy.	metalloceny
eng	Ring-substituted Vanadocene(IV) Compounds	Vanadocene(IV) complexes have raised great interests due to their biological activity. The aim of this study is to improve their cytostatic properties through substitution in cyclopentadienyl rings. The methoxy substituted vanadocenes ((C5H4R)2VCl2 (7: R = 2-CH2C6H4OMe, 8: R = 4-CH2C6H4OMe, 9: R = CH2CH2OMe) were prepared according to protocol that was previously used for the preparation of ansa-vanadocene compounds. These compounds were characterized by spectroscopic methods. The structures of 7 and 9 were determined by X-ray diffraction analysis. A low solubility of the compounds 7-9 in the therapeutic media led us to the exchange of the chlorides with more polar ligands. The amino acid complexes 10-12 were prepared according to the previously described procedure. They show sufficient solubility in the media suitable for the biological applications. Their cytostatic activity is currently under investigation.	metallocene