Publication detail

Design and efficient synthesis of amino acid derived 2-substituted imidazoles by palladium-catalyzed cross-coupling reactions

Authors: Bureš Filip | Marek Aleš | Kulhánek Jiří

Year: 2009

Type of publication: ostatní - přednáška nebo poster

Name of source: 42nd IUPAC Congress

Publisher name: Royal Society of Chemistry

Place: Cambridge

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
cze	Design and efficient synthesis of amino acid derived 2-substituted imidazoles by palladium-catalyzed cross-coupling reactions	Optically active imidazole derivatives substituted at the 2-position can be prepared in moderate to good yields by Negishi as well as Suzuki-Miyaura cross-couplings as the key synthetic steps. The reaction sequence involves N-protection, whereby both generated regioisomers could by separated by CC, and selective 2-lithiation. Subsequent transmetalation to zinc or an iodine quench affords reactants for Pd-catalyzed cross-couplings with (hetero)aromatics.	imidazole, Suzuki-Miyaura reaction, Negishi reaction
eng	Design and efficient synthesis of amino acid derived 2-substituted imidazoles by palladium-catalyzed cross-coupling reactions	Optically active imidazole derivatives substituted at the 2-position can be prepared in moderate to good yields by Negishi as well as Suzuki-Miyaura cross-couplings as the key synthetic steps. The reaction sequence involves N-protection, whereby both generated regioisomers could by separated by CC, and selective 2-lithiation. Subsequent transmetalation to zinc or an iodine quench affords reactants for Pd-catalyzed cross-couplings with (hetero)aromatics.	imidazole, Suzuki-Miyaura reaction, Negishi reaction

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