Publication detail

Interaction of the antitumor agent vanadocene dichloride with phosphate buffered saline

Authors: Vinklárek Jaromír | Honzíček Jan | Holubová Jana

Year: 2004

Type of publication: článek v odborném periodiku

Name of source: Inorganica Chimica Acta

Publisher name: Elsevier Science SA

Place: Lausanne

Page from-to: 3765-3769

Titles:

Language	Name	Abstract	Keywords
cze	Interakce antitumorově aktivního vanadocendichloridu s fosfátovým pufrem	Interakce antitumorově aktivního vanadocendichloridu s fosfátovým pufrem	vanadocene dichloride; antitumor agents; EPR spectroscopy; DFT calculations; super-hyperfine coupling
eng	Interaction of the antitumor agent vanadocene dichloride with phosphate buffered saline	EPR study has shown that in aqueous solution the anticancer agent vanadocene dichloride (Cp2VCl2) interacts with phosphates contained in phosphate buffered saline (PBS). Chelate complex Cp2VO2PO2H (\A(iso)(V)\ = 189.0 MHz, \a(iso) (P)\ = 81.5 MHz and g(iso) = 1.9862) is only one paramagnetic compound formed at the range about the physiological pH (6.3-7.8). Its structure was validated by comparison of observed and theoretical calculated HFC tensor (at the density functional level of theory). (C) 2004 Elsevier B.V. All rights reserved.	vanadocene dichloride; antitumor agents; EPR spectroscopy; DFT calculations; super-hyperfine coupling

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