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HYDROLYSIS BEHAVIOR OF THE ANTITUMOR AGENT VANADOCENE DICHLORIDE IN STRONGLY ACID, NEUTRAL AND ALKALINE AQUEOUS-MEDIA - AN EPR STUDY
Authors: Pavlík Ivan | Vinklárek Jaromír
Year: 1991
Type of publication: článek v odborném periodiku
Name of source: EUROPEAN JOURNAL OF SOLID STATE AND INORGANIC CHEMISTRY
Publisher name: GAUTHIER-VILLARS
Place: PARIS, FRANCE
Page from-to: 815-827
Titles:
Language Name Abstract Keywords
cze HYDROLYSIS BEHAVIOR OF THE ANTITUMOR AGENT VANADOCENE DICHLORIDE IN STRONGLY ACID, NEUTRAL AND ALKALINE AQUEOUS-MEDIA - AN EPR STUDY By means of EPR spectroscopy various hydrolysis species formed from the vanadocene dichloride (I), Cp2VCl2 (Cp = eta-5-C5H5), in strongly acid, neutral and alkaline aqueous solutions were identified and characterized by the measured values of isotropic spectroscopic splitting factor g(iso) and isotropic hyperfine coupling constant A(iso). In strongly acid solutions the only vanadocene species [Cp2V(H2O)2]2+ (III; g(iso) = 1.9828, A(iso) = 7.92mT) is present (stable for several days). In strongly acid 0,103M NaCl solution the prevailing species III coexists in equilibrium with [Cp2V(H2O)Cl]+ (II; g(iso) = 1.9848, A(iso) = 7.68mT). The latter complex III was identified in concentrated HCl solutions, where it coexists in equilibria with either I or III depending on the HCl concentration. Vanadocene dihydroxide, Cp2V(OH)2, (V; g(iso) = 1.9907, A(iso) = 6.285mT) was the only vanadocene complex identified at physiological and higher pH values. Its EPR signal has completely disappeared after 72h-exposure of the solution on air. EHRLICH ASCITES TUMOR; METALLOCENE DICHLORIDES; MECHANISTIC IMPLICATIONS; INHIBITION; INVITRO; V(ETA-5-C5H5)2CL2; TITANOCENE; CHEMISTRY; TITANIUM; CELLS
eng HYDROLYSIS BEHAVIOR OF THE ANTITUMOR AGENT VANADOCENE DICHLORIDE IN STRONGLY ACID, NEUTRAL AND ALKALINE AQUEOUS-MEDIA - AN EPR STUDY By means of EPR spectroscopy various hydrolysis species formed from the vanadocene dichloride (I), Cp2VCl2 (Cp = eta-5-C5H5), in strongly acid, neutral and alkaline aqueous solutions were identified and characterized by the measured values of isotropic spectroscopic splitting factor g(iso) and isotropic hyperfine coupling constant A(iso). In strongly acid solutions the only vanadocene species [Cp2V(H2O)2]2+ (III; g(iso) = 1.9828, A(iso) = 7.92mT) is present (stable for several days). In strongly acid 0,103M NaCl solution the prevailing species III coexists in equilibrium with [Cp2V(H2O)Cl]+ (II; g(iso) = 1.9848, A(iso) = 7.68mT). The latter complex III was identified in concentrated HCl solutions, where it coexists in equilibria with either I or III depending on the HCl concentration. Vanadocene dihydroxide, Cp2V(OH)2, (V; g(iso) = 1.9907, A(iso) = 6.285mT) was the only vanadocene complex identified at physiological and higher pH values. Its EPR signal has completely disappeared after 72h-exposure of the solution on air. EHRLICH ASCITES TUMOR; METALLOCENE DICHLORIDES; MECHANISTIC IMPLICATIONS; INHIBITION; INVITRO; V(ETA-5-C5H5)2CL2; TITANOCENE; CHEMISTRY; TITANIUM; CELLS

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