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Oxidative stress and its impact on development of advanced coronary artery disease
Authors: Skalický Jiří | Mužáková Vladimíra | Kanďár Roman | Meloun Milan | Vojtíšek Petr | Kovařík Jakub | Roušar Tomáš
Year: 2007
Type of publication: článek ve sborníku
Name of source: Clinical Chemistry and Laboratory Medicine Special Supplement
Publisher name: Walter de Gruyter GmbH & Co. KG
Place: Berlin
Page from-to: S241
Titles:
Language Name Abstract Keywords
cze Oxidační stres a jeho význam pro rozvoj onemocnění koronárních tepen Oxidační stres a jeho význam pro rozvoj onemocnění koronárních tepen oxidační stres; onemocnění koronárních tepen
eng Oxidative stress and its impact on development of advanced coronary artery disease Background. The disbalance of redox equilibrium plays a role in development of atherosclerosis. The aim of this study was to asses the impact of oxidative stress and antioxidative status in patients with advanced coronary artery disease. Methods. Oxidative stress parameters were determined in group of patients with serious coronary artery disease (at least 50% stenosis of the left main coronary artery or 70% stenosis of other coronary artery according to coronarographic examination; S,n=40) and control group with normal coronary artery status (C,n=38). Free radical concentration was determined by spectrophotometric assay based on chlorophyllin acceptance of electrons, total antioxidant capacity using kit TAS (Randox, UK), malondialdehyde, glutathione and a-tocopherol plasma concentration by HPLC. Plasma levels of allantoin, a-1antiproteinase, total cholesterol, triglycerides, HDL-ch, LDL-ch, fibrinogen and hsCRP were followed. Results. In patients with coronary stenosis (S) higher level of free radicals (FR) coincided with lower level of lipid standardised a-tocopherol (AT). FR: S: 5.11+-0.58mmol/l vs C: 4.60+-0.79mmol/l (p<0.01); AT: S: 2.78+-0.45umol/l vs C: 3.00+-0.39umol/l (p<0.05). In S group significantly (p<0.05) higher levels of GSSG/GSH ratio (S: 8.09+-3.86% vs C: 6.13+-2.21%), a-1antiproteinase, allantoin, triglycerides and fibrinogen were found. Conclusion. According to correlation analysis, the increased level of free radicals in patients with coronary atherosclerosis was intimately related to the presence of hypertriglyceridemia and lower levels of lipid-standardised a-tocopherol, thereby suggesting that abnormalities in both lipid metabolism and antioxidative substance levels underlie the increased oxidative stress in advanced atherosclerosis. oxidative stress; coronary artery disease

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