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Oxidative stress and inflammatory markers in advanced coronary artery disease
Authors: Mužáková Vladimíra | Skalický Jiří | Kanďár Roman | Žáková Pavla | Kovařík Jakub | Meloun Milan | Vojtíšek Petr | Roušar Tomáš
Year: 2007
Type of publication: článek ve sborníku
Name of source: Free Radical Research
Publisher name: Informa Healthcare UK
Place: London
Page from-to: S43-S44
Titles:
Language Name Abstract Keywords
cze Oxidační stres a zánětlivé markery u pokročilého onemocnění koronárních tepen Oxidační stres a zánětlivé markery u pokročilého onemocnění koronárních tepen oxidační stres; zánět; ischemická choroba srdeční
eng Oxidative stress and inflammatory markers in advanced coronary artery disease Background. The disbalance of redox equilibrium and chronic inflammatory status play a role in pathophysiology of atherosclerosis. The aim was to asses the impact of systemic inflammation, oxidative stress and antioxidative status in patients with advanced coronary artery disease. Methods. Inflammatory and oxidative stress parameters were determined in group of patients with serious coronary artery disease (at least 50% stenosis of the left main coronary artery or 70% stenosis of other coronary artery according to coronarographic examination; S, n=40) and control group of healthy people (C, n=48). Total amount of free radicals was determined by spectrophotometric assay; malondialdehyde, glutathione, homocysteine and alpha-tocopherol plasma concentrations by HPLC. Plasma levels of hsCRP, alpha1antiproteinase, total cholesterol, triglycerides, HDL-ch, LDL-ch, albumin, fibrinogen were monitored. Results. In patients with coronary stenosis (S) higher level of free radicals (FR) coincided with higher level of hsCRP and lower level of lipid standardised alpha-tocopherol (AT). FR: S: 5.11+-0.58 mmol/l vs C: 4.60+-0.79 mmol/l (p<0.01); hsCRP: S: 4.44+-2.78 mg/l vs C: 1.72+-1.19 mg/l (p<0.01); AT: S: 2.78+-0.45 micromol/l vs C: 3.26+-0.55 micromol/l (p<0.05). In S group significantly higher levels of homocysteine, alpha1antiproteinase, triglycerides, fibrinogen and lower level of albumin were found. Conclusion. Increased level of FR in patients was related to the presence of systemic inflammation and lower lipid-standardised alpha-tocopherol, suggesting that abnormalities in both chronic inflammatory status and antioxidative substance levels underlie the increased oxidative stress in advanced atherosclerosis, which is further potentiated by homocysteine, fibrinogen and lipid higher levels. Oxidative stress; inflammation; coronary artery disease

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