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GC/MS and FAB/MS ANALYSIS OF LIPID MOLECULES FOR TAXONOMIC CLASSIFICATION OF MICROORGANISMS
Authors: Miketová Petra | Khailová Ludmila | Jelínek David | Schram Karl | Moore Ida M. | Vytřasová Jarmila
Year: 2004
Type of publication: článek v odborném periodiku
Name of source: Scientific Papers of the University of Pardubice, Series A, Faculty of Chemical Technology
Publisher name: Univerzita Pardubice
Place: Pardubice
Page from-to: 131-146
Titles:
Language Name Abstract Keywords
cze GC/MS a FAB/MS analýza lipidů pro taxonomickou klasifikaci mikroorganismů. Cílem projektu bylo identifikovat přítomnost mikroorganismů v prostředí pomocí biomarkerů zjištěných GC/MS. Kombinace výsledků GC/MS a statistické vyhodnocení bylo použito k sestavení matematického modelu s definovanými parametry pro různé mikroorganismy, který klasifikuje bakterie plísně nebo viry v přírodě. Výsledky z FAB/MS analýzy ukazují rozdíly v profilech lipidů pro různé analyzované mikroorganismy. Touto metodou lze provést včasnou detekci mikroorganismů způsobujících onemocnění. GC/MS; FAB/MS; HPLC; mastné kyseliny; mikroorganismy
eng GC/MS and FAB/MS ANALYSIS OF LIPID MOLECULES FOR TAXONOMIC CLASSIFICATION OF MICROORGANISMS The goal of this project was to identify the presence of microorganisms in the enviroment by using their ga chromatography/mass spectral (GC/MS) characteristic as biomarkers. A combination of GC/MS resuts and pattern recognition statistical evaluation were used to provide a mathematical model with defined parameters for different microorganisms, wich allows the organisms to be classified as bacterial, fungal or viral in nature. Resuts from fast atom bombardment mass spectral (FAB/MS) analysis showed differences in the complex lipid profiles for most of the analyzed microorganisms. A general screening method that can provide early detection of microorganisms would permit initiation of most therapeutics. Various drugs are used to treat bacterial, fungal or viral diseases and, when treatment is started early, there is a dramatic reduction in mortality. A methodology for detection and classification of microorganisms is described in this paper. GC/MS;FAB/MS;HPLC;fatty acids;microorganisms

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