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1,1-Dimethylvanadocene -amino acid complexes: synthesis, characterization and antimicrobial behavior toward Escherichia coli B
Authors: Paláčková Hana | Vinklárek Jaromír | Holubová Jana | Frumarová Božena | Císařová Ivana | Erben Milan
Year: 2006
Type of publication: článek v odborném periodiku
Name of source: Applied Organometallic Chemistry
Publisher name: John Wiley & Sons Ltd.
Place: Chichester
Page from-to: 603-609
Titles:
Language Name Abstract Keywords
cze 1,1-Dimethylvanadocene -amino acid complexes: synthesis, characterization and antimicrobial behavior toward Escherichia coli B Eight water-soluble 1,1-dimethylvanadocene amino acid complexes have been prepared via the reaction of (MeCp)2VCl2 (2) with one equivalent of amino acid (aa) in water affording [(MeCp)2V(aa)]Cl, where aa is glycine (3), L-alanine (4), L-valine (5), L-leucine (6), L-isoleucine (7), L-phenylalanine (8), L-histidine (9) and L-tryptophane (10). All prepared complexes have been characterized by EPR, IR and Raman spectroscopy, elemental analysis and mass spectrometry. Molecular structures of [(MeCp)2V(ala)]BPh4?CH3OH (11), [(MeCp)2V(leu)]PF6 (12) and [(MeCp)2V(ile)]PF6 (13) were determined by X-ray diffraction analysis. Cytotoxic properties of complexes 2-10 were investigated toward Escherichia coli B and compared with analogical unsubstituted vanadocene compounds (1, 14-21). The results showed that 1,1-dimethylvanadocene amino acid complexes have identical or slightly higher antiproliferative activity then their unsubstituted analogs.
eng 1,1-Dimethylvanadocene -amino acid complexes: synthesis, characterization and antimicrobial behavior toward Escherichia coli B Eight water-soluble 1,1-dimethylvanadocene amino acid complexes have been prepared via the reaction of (MeCp)2VCl2 (2) with one equivalent of amino acid (aa) in water affording [(MeCp)2V(aa)]Cl, where aa is glycine (3), L-alanine (4), L-valine (5), L-leucine (6), L-isoleucine (7), L-phenylalanine (8), L-histidine (9) and L-tryptophane (10). All prepared complexes have been characterized by EPR, IR and Raman spectroscopy, elemental analysis and mass spectrometry. Molecular structures of [(MeCp)2V(ala)]BPh4?CH3OH (11), [(MeCp)2V(leu)]PF6 (12) and [(MeCp)2V(ile)]PF6 (13) were determined by X-ray diffraction analysis. Cytotoxic properties of complexes 2-10 were investigated toward Escherichia coli B and compared with analogical unsubstituted vanadocene compounds (1, 14-21). The results showed that 1,1-dimethylvanadocene amino acid complexes have identical or slightly higher antiproliferative activity then their unsubstituted analogs. bent metallocene, antitumor agents, 1,1-dimethylvanadocene dichloride, X-ray structural analysis, EPR spectroscopy, Escherichia coli

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