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Biochemical parameters of metabolic syndrome and impact of free radicals
Authors: Skalický Jiří | Votruba Milaoslav | Meloun Milan | Mužáková Vladimíra | Kovařík Jakub
Year: 2006
Type of publication: článek ve sborníku
Name of source: ATHEROSKLEROSA 2006 - diagnostika, léčba, prevence v dětském i dospělém věku
Publisher name: Česká lékařská společnost J. E. Purkyně
Place: Praha
Page from-to: 56-57
Titles:
Language Name Abstract Keywords
cze Biochemické parametry metabolického syndromu a význam volných radikálů Biochemické parametry metabolického syndromu a význam volných radikálů Volné radikály; metabolický syndrom; oxidační stres
eng Biochemical parameters of metabolic syndrome and impact of free radicals The aim of this study was to evaluate the effect of oxidative stress in obese people with metabolic syndrome (MS). Free radical plasma levels and total antioxidant capacity were determined in obese people fulfilling at least 3 criteria of MS (MS, 15 patients), obese ones without MS (OB, 18 patients), and in 48 healthy controls (C). Free radical concentration was determined by direct method based on chlorophyllin acceptance of electrons, total antioxidant capacity using the kit TAS (Randox, UK). Plasma levels of glucose, triglycerides, HDL-ch, LDL-ch, fibrinogen, uric acid and BMI, waistline and blood pressure were followed. The highest level of free radicals was found in patients with metabolic syndrome. MS: 8.68 +- 3.70 mmol/l vs OB: 6.34 +- 1.80 mmol/l (p0.05) vs C: 4.71 +- 0.77 mmol/l (p0.01). Total antioxidant capacity was low in all groups. MS: 0.91 +- 0.12 mmol/l vs OB: 0.73 +- 0.10 mmol/l (p0.05) vs C: 0.81 +- 0.09 mmol/l (p0.05). In MS group significantly (p0.05) higher levels of glucose, triglycerides and uric acid and significantly (p0.001) lower level of HDL-ch were found. Our results confirm high significance of obesity as a risk factor leading to metabolic syndrome and cardiovascular disease, respectively. High levels of free radicals together with low total antioxidant capacity detected in case of patients with metabolic syndrome indicate elevation of the oxidative stress, which potentiates risk of atherogenesis. Free radicals; metabolic syndrome; oxidative stress

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