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Publication detail

Oxidative stress and metabolic syndrome in obese patients
Authors: Mužáková Vladimíra | Skalický Jiří | Kanďár Roman
Year: 2006
Type of publication: článek ve sborníku
Name of source: The FEBS Journal Supplement
Publisher name: Blackwell Publishing Ltd
Place: Oxford
Page from-to: 201
Titles:
Language Name Abstract Keywords
cze Oxidační stres a metabolický syndrom u obesních pacientů Oxidační stres a metabolický syndrom u obesních pacientů Oxidační stres; metabolický syndrom; obesní;
eng Oxidative stress and metabolic syndrome in obese patients The aim of this study was to evaluate the effect of oxidative stress in obese people with metabolic syndrome (MS). Free radical plasma levels and total antioxidant capacity were determined in obese people fulfilling at least 3 criteria of MS (MS, 15 patients), obese ones without MS (OB, 18 patients), and in 48 healthy controls (C). Free radical concentration was determined by direct method based on chlorophyllin acceptance of electrons, total antioxidant capacity using the kit TAS (Randox, UK). Plasma levels of glucose, triglycerides, HDL-ch, LDL-ch, fibrinogen, uric acid and BMI, waistline and blood pressure were followed. The highest level of free radicals was found in patients with metabolic syndrome. MS: 8.68 +- 3.70 mmol/l vs OB: 6.34 +- 1.80 mmol/l (p0.05) vs C: 4.71 +- 0.77 mmol/l (p0.01). Total antioxidant capacity was low in all groups. MS: 0.91 +- 0.12 mmol/l vs OB: 0.73 +- 0.10 mmol/l (p0.05) vs C: 0.81 +- 0.09 mmol/l (p0.05). In MS group significantly (p0.05) higher levels of glucose, triglycerides and uric acid and significantly (p0.001) lower level of HDL-ch were found. Our results confirm high significance of obesity as a risk factor leading to metabolic syndrome and cardiovascular disease, respectively. High levels of free radicals together with low total antioxidant capacity detected in case of patients with metabolic syndrome indicate elevation of the oxidative stress, which potentiates risk of atherogenesis. Oxidative stress; metabolic syndrome; obese patients

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