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EXPERIMENTAL AND THEORETICAL STUDY OF THE FIRST VANADOCENE(IV) COMPLEXES OF a-AMINO ACID PREPARED FROM THE ANTITUMOR AGENT VANADOCENE DICHLORIDE
Authors: Vinklárek Jaromír | Paláčková Hana | Honzíček Jan | Holubová Jana | Holčapek Michal | Císařová Ivana
Year: 2006
Type of publication: článek v odborném periodiku
Name of source: Inorganic Chemistry
Publisher name: American Chemical Society
Place: Washington
Page from-to: 2156-2162
Titles:
Language Name Abstract Keywords
cze EXPERIMENTAL AND THEORETICAL STUDY OF THE FIRST VANADOCENE(IV) COMPLEXES OF a-AMINO ACID PREPARED FROM THE ANTITUMOR AGENT VANADOCENE DICHLORIDE The first bioinorganic vanadocene(IV) complexes of a-amino acid ([Cp2Vaa]Cl; aa = glycine, L-alanine, L-valine) were prepared by reaction of antitumor active vanadocene dichloride [Cp2VCl2] (Cp = h5-C5H5) (1) and a-amino acids in aqueous methanol. Analogous PF6- ionic complexes were obtained by methathetical reactions of chloride complexes with KPF6. These compounds are of great interest as the model systems for the vanadocene moiety-binding to proteins. All complexes have been characterized by elemental analyses, IR and Raman spectroscopy and especially by EPR spectroscopy. On the basis of EPR spectra was suggested the chelate bound in all the studied complexes that is realize via the carboxylato and amino groups. This structure was also confirmed by DFT calculations. vanadocene dichloride, amino acid, antitumor activity, EPR spectroscopy, DFT.
eng EXPERIMENTAL AND THEORETICAL STUDY OF THE FIRST VANADOCENE(IV) COMPLEXES OF a-AMINO ACID PREPARED FROM THE ANTITUMOR AGENT VANADOCENE DICHLORIDE The first bioinorganic vanadocene(IV) complexes of a-amino acid ([Cp2Vaa]Cl; aa = glycine, L-alanine, L-valine) were prepared by reaction of antitumor active vanadocene dichloride [Cp2VCl2] (Cp = h5-C5H5) (1) and a-amino acids in aqueous methanol. Analogous PF6- ionic complexes were obtained by methathetical reactions of chloride complexes with KPF6. These compounds are of great interest as the model systems for the vanadocene moiety-binding to proteins. All complexes have been characterized by elemental analyses, IR and Raman spectroscopy and especially by EPR spectroscopy. On the basis of EPR spectra was suggested the chelate bound in all the studied complexes that is realize via the carboxylato and amino groups. This structure was also confirmed by DFT calculations. vanadocene dichloride, amino acid, antitumor activity, EPR spectroscopy, DFT.

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