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Evaluation of oxidative stress and inflammation in obese adults with metabolic syndrome.
Authors: Skalický Jiří | Mužáková Vladimíra | Kanďár Roman | Meloun Milan | Roušar Tomáš | Palička Vladimír
Year: 2008
Type of publication: článek v odborném periodiku
Name of source: Clinical Chemistry and Laboratory Medicine
Publisher name: Walter de Gruyter GmbH & Co. KG
Place: Berlin
Page from-to: 499-505
Titles:
Language Name Abstract Keywords
cze Zhodnocení oxidačního stresu a zánětu u obezních osob s metabolickým syndromem Zhodnocení oxidačního stresu a zánětu u obezních osob s metabolickým syndromem metabolický syndrom; oxidační stres; zánět
eng Evaluation of oxidative stress and inflammation in obese adults with metabolic syndrome. Background: Obesity and metabolic syndrome increase the risk of cardiovascular morbidity and mortality. Oxidative stress seems to be involved in pathophysiology of diabetes and cardiovascular complications of metabolic syndrome. The aim of our study was to evaluate the level of oxidative stress and inflammation in obese adults with and without metabolic syndrome. Methods: Oxidative stress and inflammation markers (total amount of free radicals, malondialdehyde, allantoin, a1antiproteinase, GSSG/GSH ratio, hsCRP, fibrinogen), total antioxidant capacity and lipid standardized a-tocopherol were determined in obese people fulfilling at least 3 criteria of metabolic syndrome according to NCEP ATP III (20 patients), in obese people without metabolic syndrome (20 patients) and in 48 healthy controls. Results: Oxidative stress and inflammation markers were significantly elevated in the obese individuals, especially those exhibiting metabolic syndrome. According to multidimensional statistical analysis, oxidative stress was independently related to triacylglyceride concentration, abdominal fat, low HDL-C and low lipid standardized a-tocopherol in the patients with MetS. Conclusions: High levels of free radicals together with low antioxidant capacity detected in obese adults indicate elevated oxidative stress, which is - together with systemic inflammation - further potentiated in the case of obese patients with metabolic syndrome. This imbalance in oxidative/antioxidative status and subclinical inflammatory state lead to a higher risk of atherosclerotic and diabetic complications. inflammation; metabolic syndrome; oxidative stress

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