Login for students

Login for employees

Publication detail

High Hepatic Stearoyl-CoA Desaturase-1 (SCD-1) Index is associated with low Liver Fat and high Insulin Sensitivity in obese Humans
Authors: Stefan N | Čegan Alexander | Staiger H | Machann J | Schick S | Fritsche A | Haring H | Schleicher E
Year: 2006
Type of publication: článek ve sborníku
Name of source: Diabetes
Publisher name: American Diabetes Association
Place: Alexandria
Page from-to: A331
Titles:
Language Name Abstract Keywords
cze Vysoký index jaterní stearoyl-CoA desaturasy?1 (SCD-1) souvisí s nízkým obsahem jaterního tuku a vysokou citlivostí k insulinu u obézních lidí Vysoký index jaterní stearoyl-CoA desaturasy?1 (SCD-1) souvisí s nízkým obsahem jaterního tuku a vysokou citlivostí k insulinu u obézních lidí stearoyl-CoA desaturasa, jaterní tuk, citlivost k insulinu, obezita
eng High Hepatic Stearoyl-CoA Desaturase-1 (SCD-1) Index is associated with low Liver Fat and high Insulin Sensitivity in obese Humans SCD-1 catalyzes the synthesis of monounsaturated fatty acids (FA) from saturated FA. It is imperative for the assembly of very low density lipoprotein (VLDL) particles, which transport FA from liver to adipose tissue and other sites. Studies in animals suggest that SCD-1 deficiency is beneficial for metabolism. However, in humans data are conflicting. We applied an elaborate method to measure an index of hepatic SCD-1 activity. First, we determined the pattern of FA in the lipid fraction of the VLDL triglycerides by ultracentrifugation followed by thin layer and gas chromatography in plasma samples from 54 healthy subjects. The oleoyl-CoA (C18:1, n9) / stearoyl-CoA (C18:0) ratio was calculated as an index of hepatic SCD-1 activity, thereafter. Insulin sensitivity (IS) was estimated from an oral glucose tolerance test (OGTT) and determined during a euglycemic clamp (n=48). Liver fat was measured by 1H magnetic resonance spectroscopy. Gender distribution, mean age and body fat were as follows: 26 m/28 f, 44?2 y, 31?1 %. The hepatic SCD-1 activity index was negatively associated with liver fat (r=-0.28, p=0.049), independently of age, gender and body fat. It was positively associated with IS(OGTT) (r=0.42, p=0.002) and more weakly with IS(clamp) (r=0.27, p=0.07). Importantly, these relationships were dependent on overall adiposity. When subjects were divided in a lean (n=27, 26 ?5 %) and in an obese (n=27, 35 ?6 %) group by the median body fat, the significant relationships were absent in the lean group (liver fat: p=0.34, IS(OGTT): p=0.75, IS(clamp): p=0.24). However, they were strengthened in the obese group (p=0.004, p=0.0002, p=0.006). After a 9 month lifestyle intervention with diet and increase in physical activity, a high SCD-1 activity index at baseline was associated with a larger increase in IS(clamp, adjusted) in the obese (p=0.04) but not in the lean (p=0.35) group. We conclude that hepatic SCD-1 may be an important regulator of liver fa stearoyl-CoA desaturase-1; liver fat; insulin sensitivity; obesity

Departments

Other Parts

Map

en.mapy.cz

Services

Popular Links

© 2023 University of Pardubice, Studentská 95, 532 10 Pardubice 2
Phone: +420 466 036 111, 466 036 112, 466 036 113
Webmaster, RSS
Data box ID: f5vj9hu
Accessibility Statement
CC BY-NC-ND 4.0