Publication detail

Fatty liver is strongly associated with a qualitative change in the serum HDL cholesterol sub-fractions

Authors: Stefan Norbert | Kantartzis Konstantinos | Čegan Alexander

Year: 2007

Type of publication: článek ve sborníku

Name of source: Diabetes

Publisher name: American Diabetes Association

Place: Alexandria

Page from-to: A680-A680

Titles:

Language	Name	Abstract	Keywords
cze	Steatóza jater silně souvisí s kvalitativní změnou subfrakcí sérového HDL-cholesterolu	Steatóza jater silně souvisí s kvalitativní změnou subfrakcí sérového HDL-cholesterolu	steatóza, játra, jaterní tuk, HDL-C, subfrakce
eng	Fatty liver is strongly associated with a qualitative change in the serum HDL cholesterol sub-fractions	Nonalkoholic fatty liver disease increases in the general population in paralel to the increase in obesity. It is commonly associated with features of metabolic syndrome such as abdominal obesity, high triglyceride levels, low high-density lipoprotein cholesterol (HDL-C) levels, high blood pressure and hyperglycaemia. Patiens with NAFLD (nonalkoholic fatty liver disease) are at increased risk for atherosclerosis and cardiovascular events. Mechanisms explaining the relationship between NAFLD and atherosclerosis are still under investigation. Whether NAFLD is associated with altered serum high-density cholesterol subfractions HDL2 and HDL3 that were found to have a large impact on cardiovascular disease, is unknown. Particularly high HDL2 levels were found to be protective of cardiovascular events. In the prezent study we investigated whether patiens with NAFLD have different serum levels of HDL subfractions compared to healthy controls and whether these relationships are independent of other established cardiovascular risk factors that are commonly increased in patiens with NAFLD.	steatosis; liver; liver fat; HDL-C; subfraction

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