Publication detail

Basic rules for the interpretation of atmospheric pressure ionization mass spectra of small molecules

Authors: Holčapek Michal | Jirásko Robert | Lísa Miroslav

Year: 2010

Type of publication: článek v odborném periodiku

Name of source: Journal of Chromatography A

Publisher name: Elsevier Science BV

Place: Amsterdam

Page from-to: 3908-3921

Titles:

Language	Name	Abstract	Keywords
cze	Základní pravidla pro interpretaci API hmotnostních spekter malých molekul	Review shrnuje základní pravidla pro interpretaci API hmotnostních spekter malých molekul a je určeno převážně pro začátečníky a mírně pokročilé uživatele.	ESI, APCI, APPI
eng	Basic rules for the interpretation of atmospheric pressure ionization mass spectra of small molecules	This review summarizes the basic rules for the interpretation of atmospheric pressure ionization (API) mass spectra of small molecules written with the style primarily intended for beginners and low-experienced researchers with the mass spectra interpretation. The first and basic step in any interpretation of mass spectra is always the determination of molecular weight, which is relatively easy in case of soft ionization techniques due to the limited extend of fragmentation and the prevailing presence of (de)protonated molecules in the full scan mass spectra. The subsequent interpretation of full scan and tandem mass spectra is more complicated due to a high number of possible functional groups, structural subunits and their combinations resulting in numerous competitive fragmentation pathways. Typical neutral losses and the effect of individual functional groups on the fragmentation are discussed in detail and illustrated with selected examples.	Mass spectra; Mass spectrometry; Interpretation; Electrospray ionization; Atmospheric pressure chemical ionization; Atmospheric pressure photoionization

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