Publication detail

Studium DNA modifikované komplexy platiny na rtuťových elektrodách

Year: 2010

Type of publication: článek ve sborníku

Name of source: Sborník přednášek mezinárodní odborné konference XXX. Moderní elektrochemické metody

Publisher name: BEST Servis

Place: Ústí nad Labem

Page from-to: 187-191

Titles:

Language	Name	Abstract	Keywords
cze	Studium DNA modifikované komplexy platiny na rtuťových elektrodách	Byly prováděny voltametrické studie DNA modifikovaných cisplatinou, oxaliplatinou a carboplatinou na rtuťových elektrodách. Během square wave voltametrie katalytické proudy tvoří dobře detekovatelný a analyticky využitelný pík (pík P). Intenzita píku P odpovídá modifikaci DNA relevantní pro biochemické studie (rb = 0,01 – 0,10, kde rb je poměr platina/ nukleotid).	Elektrochemická analýza; cisplatina; oxaliplatina; karboplatina; protinádorová léčiva; DNA
eng	Monitoring DNA Modification by Platinum Complexes at Mercury electrodes	Covalently attached metal-containing groups usually render the DNA well-pronounced electrochemical activity related to redox processes of the metal moieties, which can in some cases be coupled to catalytic hydrogen evolution at mercury electrodes. We used voltammetry at the mercury electrodes for the monitoring of DNA modification with cis-diamminedichloroplatinum (cisplatin), [(1R,2R)-cyclohexane-1,2-diamine](ethanedioato-O, O')platinum(II) (oxaliplatin) and cis-diammine(cyclobutane-1,1-dicarboxylate-O, O') platinum(II) (carboplatin). In square-wave voltammetry, during anodic polarization after pre-reduction of the platinated DNA, a well developed signal (peak P) was obtained. Intensity of the peak P responded to the extent of DNA modification at rb = 0.01 - 0.10, where rb is the number of platinum atoms bound per DNA nucleotide.	Electrochemical analysis; Cisplatin; Oxaliplatin; Carboplatin; Antitumor drugs; DNA

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