Publication detail

UV-VIS spectroscopy in the determination of dissociation constats of some dronates

Authors: Ferenčíková Zuzana | Meloun Milan | Pekárek Tomáš

Year: 2011

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	UV-VIS spectroscopy in the determination of dissociation constats of some dronates	The mixed dissociation constants of two nitrogen-containing bisphosphonates acids HJL, alendronate and risedronate at various ionic strengths I and at 25°C and at 37°C have been determined with the use of the nonlinear regression analysis of the multiwavelength spectrophotometric pH-titration data.In general, all three N-BPs are pentaprotic acids, but after dissolution, they may be treated as tetraprotic or triprotic acids. pH-titration of tetraprotic weak acid H4L with a strong base (e.g. NaOH) involves eight solution species H3O+, OH-, H4L, H3L-, H2L2-, HL3-, L4-, and the sodium cation Na+.	spectral analysis;dissociaiton constant;alendronate;risedronate

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