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In vitro and in vivo studies of praziquantel and its metabolites using UHPLC/MS/MS
Authors: Jedličková Veronika | Jirásko Robert | Holčapek Michal | Vokřál Ivan | Skálová Lenka
Year: 2011
Type of publication: ostatní - přednáška nebo poster
Page from-to: nestránkováno
Titles:
Language Name Abstract Keywords
eng In vitro and in vivo studies of praziquantel and its metabolites using UHPLC/MS/MS In this work, in vitro and in vivo studies of anthelminthic drug praziquantel were performed. The solid-phase extraction method was optimized for incubation mixtures. Extracted samples were subsequently analysed by UHPLC/MS/MS with the emphasis to detect and identify phase I and II metabolites of praziquantel. praziquantel;drug metabolites;UHPLC/MS/MS