Publication detail

Is rat liver affected by non-alcoholic steatosis more susceptible to the acute toxic effect of thioacetamide?

Year: 2011

Type of publication: článek v odborném periodiku

Name of source: International Journal of Experimental Pathology

Publisher name: Wiley-Blackwell

Page from-to: 281-289

Titles:

Language	Name	Abstract	Keywords
cze	Jsou steatotická játra vnímavější k akutnímu poškození thioacetamidem?	Je pouze několik vědeckých prací zabývajících se tímto tematem, a proto bylo naším hlavním cílem se zaměřit na problematiku steatózy a s ní spojeným akutním poškozením hepatocytů.	Thioacetamid;NAFLD;játra
eng	Is rat liver affected by non-alcoholic steatosis more susceptible to the acute toxic effect of thioacetamide?	There is only little evidence about altered sensitivity of steatotic liver to acute toxic injury. The aim of this project was to compare acute toxic effect of a model hepatotoxin thioacetamide (100 mg/ kg) on intact rat liver and rat liver affected by high-fat diet-induced non-alcoholic fatty liver disease (NAFLD). Serum biochemical parameters (ALT, AST, ALP, and bilirubin) and TNFalpha, hepatic IL-6 and TGFbeta1 and centrilobular necrosis with subsequent regenerative response of the liver were significantly higher in high-fat diet fed rats after thioacetamide administration. Steatotic rat liver, compared to non-steatotic liver, is more sensitive to acute toxic effect of thioacetamide.	Thioacetamide; NAFLD; liver

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