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Intramolecular Buchwald-Hartwig Amination of Some Cyclic Enaminones

Authors: Šimůnek Petr

Year: 2012

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Intramolecular Buchwald-Hartwig Amination of Some Cyclic Enaminones	During the past several decades, C–N cross-coupling has become a useful and powerful methodology in the toolbox of a synthetic organic chemist (from many reviews see . At present, applications of the method for the synthesis of pharmaceutics, natural products as well as advanced materials have been described. As the substrates both aromatic and aliphatic amines together with imines and hydrazones can be used. However only a little amount of information is published on the application of Buchwald-Hartwig amination for such an important class of substrates as enaminones. In the presented work, an intramolecular Pd-catalysed C–N cross coupling of enaminones I is described. The optimization of the reaction conditions is to be discussed.	Buchwald-Hartwig amination; Enaminones