Publication detail

The Differences Between Aromatizable and Non-Aromatizable Androgens in Relation to Body Composition and Metabolic Syndrome Risk Factors in Men

Year: 2012

Type of publication: článek v odborném periodiku

Name of source: Journal of Steroid Biochemistry and Molecular Biology

Publisher name: Pergamon-Elsevier Science Ltd.

Place: Oxford

Page from-to: 105-111

Titles:

Language	Name	Abstract	Keywords
cze	Rozdíl mezi aromatizovatelnými a nearomatizovatelnými androgeny ve vztahu k tělesným proporcím a faktorům metabolického symdromu u mužů	V literatue je často diskutován vztah meti parametry metabolického symdramu a nearomatizovatelnými metabolity testosteronu. Někteří autoři popisují tyto metabolity jako příčiny vzniku mužské obezity. Naopak jiné studie popisují ochranný vliv dihydrotestosteronu na viscerální obezitu. Cílem této studie je analzování vztahu mezi antropometrickými parametry, spektra lipidů, glykémie a úrovně endrogenního testosteronu a dihydrogentestosteronu a porovnat efekt těchto androgenů. Byla změřena hladina testosteronu, dihydrotestosteronu a úroveň pohlavního hormonu vázajícího globulin SHBG, spektrum lipidů a metabolismus glukózy a také byl proveden glukózový toleranční test u všech subjektů. Jejich antropogenní parametry (váha, výška, obvod pasu, obvod boků, poměr pas/boky, 14 kožních záhybů) a parametry tělesné proporce byly získány pomocí programu Antropo. Vícerozměrná regresní analýzy ukazuje na korelaci mezi hladinou hormonů a antropometrickými daty, spektrem lipidů a parametrů glukózové regulace. Nízká hladina testosteronu a/nebo dihydrotestosteronu korelovala s vysokým BMI, obsahem tuků, obvodem pasu, celkovým, HDL- a LDL- cholesterolem a triglyceridy.	dihydrotestosteron; testosteron; ukládání tuků; antropometrické parametry; inzulínová rezistence
eng	The Differences Between Aromatizable and Non-Aromatizable Androgens in Relation to Body Composition and Metabolic Syndrome Risk Factors in Men	The relationships between the parameters of metabolic syndrome and non-aromatizable metabolites of testosterone have been discussed in literature. Some papers describe these metabolites as one of the possible causes of male-type obesity. On the contrary, other studies show a protective influence of dihydrotestosterone on visceral obesity. The aim of this study to analyse the relationship between anthropometric parameters, lipid spectrum, glycemia and the level of endogenous testosterone and dihydrotestosterone, and to compare the effects of these androgens. Serum testosterone, dihydrotestosterone and sex hormone binding globulin SHBG levels, lipid spectrum, glucose metabolism parameters were measured and the oral glucose tolerance test was carried out in all subjects. Their anthropometric parameters (weight, height, waist, hips, waist-to-hip ratio, 14 skin folds) and body composition parameters were determined and calculated by the Antropo program. Multiple regression analysis showed a correlation between hormonal levels, esp. of testosterone and dihydrotestosterone, and the anthropometric data, lipid spectrum and parameters of glucose regulation. Low testosterone and/or dihydrotestosterone was correlated to a higher body-mass index, fat content, waist diameter, total-, HDL-, LDL-cholesterol and triglycerides, fasting glucose, insulin resistance and lower muscle and bone mass. In addition, statistical analysis using multivariate regression with reduction in dimensionality did not discover any striking difference between aromatizable and non-aromatizable androgens in their association to lipid and glucose metabolism parameters in healthy, normosthenic men. In conclusion, the association of endogenous testosterone and dihydrotestosterone to anthropometric data, lipid spectrum and insulin sensitivity are of the same quality; however, the effect of the circulating levels of dihydrotestosterone is quantitatively smaller.	dihydrotestosterone; testosterone; fat deposition; anthropometric parameters; insulin resistance

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