Login for students

Login for employees

Publication detail

Synthesis and Cytostatic activity of Pt(II) complexes of intramolecularly coordinated phosphine and stibine ligands
Authors: Řezníček Tomáš | Dostál Libor | Růžička Aleš | Vinklárek Jaromír | Řezáčová Martina | Jambor Roman
Year: 2012
Type of publication: článek v odborném periodiku
Name of source: Applied Organometallic Chemistry
Publisher name: John Wiley & Sons Ltd.
Place: Chichester
Page from-to: 237-245
Titles:
Language Name Abstract Keywords
cze Syntéza a cytotoxická aktivita Pt komplexů obsahujících fosfínové a stibinové ligandy. Intramolekulárně koordinované fosfíny a stibiny L1PPh2 (1), L2PPh2 (2) a L2SbPh2 (3) byly připraveny. Tyto ligandy byly použity na přípravu platnatých komplexů trans-{[2,6-(tBuOCH2)2C6H3]PPh2}2PtCl2 (4), cis-{[2,6-(Me2NCH2)2C6H3]PPh2}PtCl2 (5), a cis-{[2,6-(Me2NCH2)2C6H3]SbPh2}PtCl2 (6). Y, C, Y-ligandy, platina, cheláty, biologické testy, cytotoxická studie
eng Synthesis and Cytostatic activity of Pt(II) complexes of intramolecularly coordinated phosphine and stibine ligands The intramolecularly coordinated phosphine and stibine ligands L1PPh2 (1), L2PPh2 (2) and L2SbPh2 (3) containing Y,C,Y-chelating ligands, L1?=?2,6-(tBuOCH2)2C6H4- and L2?=?2,6-(Me2NCH2)2C6H4-, were prepared and characterized. The treatment of these ligands 13 with PtCl2 yielded complexes trans-{[2,6-(tBuOCH2)2C6H3]PPh2}2PtCl2 (4), cis-{[2,6-(Me2NCH2)2C6H3]PPh2}PtCl2 (5), and cis-{[2,6-(Me2NCH2)2C6H3]SbPh2}PtCl2 (6) as the result of different ability of the starting compounds 13 to complex platinum centre. Compounds 16 were characterized by 1H, 13C and 31P NMR spectroscopy and electrospray ionization mass spectrometry, and molecular structures of 36 were determined by X-ray diffraction analysis. The substitution reactions of complexes 46 were also studied. The reaction of 5 and 6 with NaI yielded complexes {[2,6-(Me2NCH2)2C6H3]PPh2}PtI2 (7) and {[2,6-(Me2NCH2)2C6H3]SbPh2}PtI2 (8), while the same reaction of 4 with NaI did not proceed. As the compounds 7 and 8 structurally resemble cisplatin, complex {{[2-(Me2NCH2)-6-(Me2NHCH2)C6H3]PPh2}PtCl2}+Cl- (9) was prepared as water-soluble platinum complex. The cytotoxic effect of complex 9 was evaluated. Y; C; Y-ligands; platinum; chelates; biological tests; cytotoxic study

Departments

Other Parts

Map

en.mapy.cz

Services

Popular Links

© 2023 University of Pardubice, Studentská 95, 532 10 Pardubice 2
Phone: +420 466 036 111, 466 036 112, 466 036 113
Webmaster, RSS
Data box ID: f5vj9hu
Accessibility Statement
CC BY-NC-ND 4.0Creative CommonsAttributionNonCommercialNoDerivatives