Publication detail

Alpha-amino acids as precursors in the synthesis of optically active benzo[d]imidazoles

Authors: Mohite Pravinkumar Hansraj | Bureš Filip

Year: 2013

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Alpha-amino acids as precursors in the synthesis of optically active benzo[d]imidazoles	As a continuation of our recent research on optically active imidazole derivatives,1-3 a five step reaction sequence leading to the synthesis of new alpha-amino acid-derived benzimidazoles has been developed. In the present study, a series of novel benzo[d]imidazole derivatives was synthesized. Commercially available and inexpensive essential alpha-amino acids were chosen as a source of chirality to make the entire synthesis low-cost. The alpha-amino acids such as L-Ala, D-Ala, L,D-Ala, L-Leu, L-iLeu, L-Phe, L-Val, and L-Pro were utilized in this reaction (Scheme1). These optically active molecules can be utilized as precursors for the construction of higher heterocyclic systems or can directly be employed as nitrogen ligands in a selected asymmetric reaction.	alpha-AMINO ACIDS; BENZOdIMIDAZOLES; LIGANDS

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