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Biotransformation of Benzimidazole Anthelmintics in Reed (Phragmites australis) as a Potential Tool for their Detoxification in Environment
Authors: Podlipná Radka | Skálová Lenka | Seidlová Helena | Szotáková Barbora | Kubíček Vladimír | Stuchlíková Lucie | Jirásko Robert | Vaněk Tomáš | Vokřál Ivan
Year: 2013
Type of publication: článek v odborném periodiku
Name of source: Bioresource Technology
Publisher name: Elsevier Science BV
Place: Amsterdam
Page from-to: 216-224
Titles:
Language Name Abstract Keywords
cze Biotransformace benzimidazolových anthelmintik v rákosu (Phragmites australis), potenciální nástroj pro jejich detoxikaci v životním prostředí Benzimidazolová anthelmintika, léčiva využívaná proti parazityckým červům, jsou využívány jak v lékařství, tak ve veterinářství. Tyto látky mohou dále zůstávat v životním prostředí a mít negativní dopad na přítomné organismy. Z těchto důvodů byl zkoumán metabolismus vybraných anthelmintik v rákosu, jakožto potenciálního nástroje pro odbourání nežádoucích léčiv z kontaminovaného prostředí. metabolismus léčiv; biotransformace; albendazole; flubendazole
eng Biotransformation of Benzimidazole Anthelmintics in Reed (Phragmites australis) as a Potential Tool for their Detoxification in Environment Benzimidazole anthelmintics, the drugs against parasitic worms, are widely used in human as well as veterinary medicine. Following excretion, these substances may persist in the environment and impact non-target organisms. In order to test phytoremediation as a possible tool for detoxification of anthelmintics in environment, the biotransformation pathways of albendazole (ABZ) and flubendazole (FLU) were studied in reed (Phragmites australis) in vitro. Reed cells were able to uptake and biotransform both anthelmintics. Ten ABZ metabolites and five FLU metabolites were found. Some atypical biotransformation reactions (formation of glucosylglucosides, acetylglucosides and xylosylglucosides), which have not been described previously, were identified. Based on the obtained results, the schemes of metabolic pathways of ABZ and FLU in reed were proposed. Most of ABZ and FLU metabolites can be considered as anthelmintically less active; therefore uptake and biotransformation of these anthelmintics by reed could be useful for decrease of their toxicity in environment. Drug-metabolism; Phytotransformation; Albendazole; Flubendazole; Phytoremediation

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