Publication detail

Toxicity of the mycotoxin ochratoxin A in the light of recent data

Authors: Malíř František | Ostrý Vladimír | Novotná Eva

Year: 2013

Type of publication: článek v odborném periodiku

Name of source: Toxin Reviews

Publisher name: Informa Healthcare UK

Place: London

Page from-to: 19-33

Titles:

Language	Name	Abstract	Keywords
cze	Toxicita mykotoxinu ochratoxinu A ve světle současných znalostí	Ochratoxin A (OTA) je ubikvitní přirozeně se vyskytující mykotoxin produkovaný v kontaminované potravě rodem Penicillium a Aspergilus. OTA se ukázal být nefrotoxický, hepatotoxický, teratogenní, imunotoxický, neurotoxický, genotoxický a karcinogenní. Jeho metabolismus, genotoxicita a mechanismus působení je diskutován.	ochratoxin A; toxicita; lidské zdraví
eng	Toxicity of the mycotoxin ochratoxin A in the light of recent data	Ochratoxin A (OTA) is a ubiquitous, naturally occurring chlorophenolic mycotoxin produced in contaminated food and feed by fungi of genera Penicillium and Aspergillus. OTA is a common contaminant of various foodstuffs of both plant and animal origin. OTA represents significant risk to human and animal health. OTA has been shown to be nephrotoxic, hepatotoxic, teratogenic, immunotoxic, neurotoxic, genotoxic and carcinogenic (possible human carcinogen-group 2B), being characterized by species and sex differences in sensitivity. In some aspects OTA remains as a controversial topic. Its metabolism, genotoxicity and mechanism of action for renal carcinogenicity have been discussed.	exposure; human health; metabolites; ochratoxin A; toxicity

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