Publication detail

Synthesis of substituted 5-(2-hydroxyphenyl)-1,3-thiazol-4-oles as pH switchable fluorophores

Authors: Kammel Richard | Hanusek Jiří

Year: 2014

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Synthesis of substituted 5-(2-hydroxyphenyl)-1,3-thiazol-4-oles as pH switchable fluorophores	Present work is a continuation of our previous research1 done in the field of transformation reaction of isothiuronium salts derived from various lactones2 and lactames3 giving substituted 2-iminothiazolidin-4-ones or 2-aminothiazolin-4-ones. These compounds are known e.g. for their significant biological activity but they do not possess any fluorescence behaviour. On the other hand some substituted 1,3-thiazol-4-oles are good fluorophores4 in solutions and sometimes also in solid state. It is also known that the presence of some ionizable groups (OH, NH2 etc.) can significantly affect the shift of their UV absorption/fluorescence band. Therefore we have prepared a new set of substituted 5-(2-hydroxyphenyl)-1,3-thiazol-4-oles (1a-h) and studied their spectral properties under various conditions.	Synthesis; 5-(2-hydroxyphenyl)-1,3-thiazol-4-oles; fluorophor

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