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pH Switchable fluorophores based on 5-(2-hydroxyphenyl)-1,3-thiazol-4-oles

Authors: Kammel Richard | Hanusek Jiří

Year: 2014

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	pH Switchable fluorophores based on 5-(2-hydroxyphenyl)-1,3-thiazol-4-oles	1,3-Thiazol-4-oles are good fluorophores4 in solutions and sometimes also in solid state. It is also known that the presence of some ionizable groups (OH, NH2 etc.) can significantly affect the shift of their UV absorption/fluorescence band. For preparation of 1,3-thiazol-4-oles we used aromatic thioamides as a starting material. We have prepared a new set of substituted 5-(2-hydroxyphenyl)-1,3-thiazol-4-oles (1a-g) and studied their spectral properties under various conditions. The title compounds were prepared from 3-bromocoumaran-2-one and aromatic thioamides in acetonitrile. After one hour hydrobromides of substituted 1,3-thiazol-4-oles have been isolated which have been subsequently converted to 1a-g using suitable base (aq. NH3)	fluorophor; 5-(2-hydroxyphenyl)-1,3-thiazol-4-oles, pH-dependence