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Synthesis of substituted tetrahydroquinolines by the intramolecular N-arylation of enaminones

Authors: Doušová Hana | Horák Radim | Šimůnek Petr | Padělková Zdeňka

Year: 2014

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Synthesis of substituted tetrahydroquinolines by the intramolecular N-arylation of enaminones	We developed a simple, new method for synthesis of 2-aroylmethylidene-1,2,3,4-tetrahydroquinolines via an intramolecular transition-metal catalyzed N-arylation of enaminones containing bromine or chlorine atom. The appropriate conditions for the cyclization of the enaminones were found according to the optimization study. The prepared tetrahydroquinolines are the direct precursor of Galipea Officinalis tetrahydroquinoline alkaloids.	tetrahydroquinolines; N-arylation; enaminones