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Novel Nanocrystalline Diamond Coating of Coronary Stents Reduces Neointimal Hyperplasia in Pig Model
Authors: Kocka V. | Jirasek T. | Taylor A. | Fendrych F | Rezek B. | Simunkova Z. | Mrazova I | Tousek P. | Mistrík Jan | Mandys V | Nesladek M
Year: 2014
Type of publication: článek v odborném periodiku
Name of source: Experimental and Clinical Cardiology
Publisher name: Cardiology Academic Press
Place: Bern
Page from-to: 65-76
Titles:
Language Name Abstract Keywords
cze Nové diamantové nanokrystalické povlaky koronárních stentů pro sníženou neointimální hyperplasii v prasečím modelu Tato práce posuzuje využití nových diamantových nanokrystalických povlaků koronárních stentů pro sníženou neointimální hyperplasii v prasečím modelu Stent; nanotechnologie; restenoza; optick8 koherenční tomografie
eng Novel Nanocrystalline Diamond Coating of Coronary Stents Reduces Neointimal Hyperplasia in Pig Model Objectives: This study sought to study the performance of nanocrystalline diamond (NCD) coated stainless steel (SS) coronary stent in a pig coronary artery model. Background: Diamond is hard, biocompatible material which offers the possibility of functionalization by covalent carbon chemistry. Methods: Unique microwave plasma enhanced chemical vapour deposition system enabled NCD coating of SS coronary stents with a uniform thickness of 120 nm. Good mechanical properties of this thin coating were demonstrated ex vivo by scanning electron microscopy previously. 26 coronary stents (13 NCD coated and 13 SS) were implanted in a randomized fashion into pig coronary arteries with balloon/artery ratio equal to 1.2. The area of neointimal hyperplasia, late loss and stent strut apposition was evaluated in a standard fashion by optical coherence tomography at 6 weeks. Results: All animals survived and all stents were patent at 6 weeks. There was no difference in proximal or distal reference segment size or stent area between NCD and SS group. However, there was a significantly larger lumen area in the NCD group (4.8±0.97 versus 3.85±0.87 mm2, p=0.02). The neointimal hyperplasia area was smaller in the NCD group by 37% (1.57±0.63 mm2 in NCD group versus 2.39±0.87 mm2 in SS group, p=0.02). There was no difference in stent strut apposition and coverage between NCD and SS group. Conclusion: Implantation of nanocrystalline diamond coated coronary stent significantly reduces neointimal hyperplasia by 37% in comparison to identical stainless steel stent and appears to be safe with very low incidence of non-apposed or uncovered struts. Stents; Nanotechnology; Restenosis; Optical coherence tomography; Diamond

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