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Ring-functionalized niobocene complexes
Authors: Honzíčková Iva | Honzíček Jan | Vinklárek Jaromír | Padělková Zdeňka | Řezáčová Martina | Šebestová Lucie
Year: 2014
Type of publication: článek v odborném periodiku
Name of source: Applied Organometallic Chemistry
Publisher name: John Wiley & Sons Ltd.
Place: Chichester
Page from-to: 252-258
Titles:
Language Name Abstract Keywords
cze Niobocenové komplexy substituované na cyklopentadienylových kruzích Nové niobocenové komplexy substituované na cyklopentadienylových kruzích (RCH2C5H4)(2)NbCl2 (R=MeOCH2, (CH2)(5)NCH2, 2-MeOC6H4, 3-MeOC6H4, 4-MeOC6H4, 2,4-(MeO)(2)C6H3, 3,4-(MeO)(2)C6H3, 2,4,6-(MeO)(3)C6H2, 3,4,5-(MeO)(3)C6H2, 4-FC6H4, 4-Me2NC6H4) byly pripraveny a charakterizovány EPR spektroskopií. Struktury tři sloučenin byly určeny RTG-difrakční analýzou. Tato studie ukázal, že substituce methoxybenzylovými skupinami vede k vysoce aktivním částicím. Nejaktivnější sloučeninou byl {2,4-(MeO)(2)C6H3CH2C5H4}(2)NbCl2 jeho IC50 jse srovnatelné s cisplatinou. metallocendihalogenidy; cytotoxicita; EPR spektroskopie; RTG diffrakční analýza; leukemie
eng Ring-functionalized niobocene complexes A series of new ring-functionalized niobocene dichloride compounds (RCH2C5H4)(2)NbCl2 (R=MeOCH2, (CH2)(5)NCH2, 2-MeOC6H4, 3-MeOC6H4, 4-MeOC6H4, 2,4-(MeO)(2)C6H3, 3,4-(MeO)(2)C6H3, 2,4,6-(MeO)(3)C6H2, 3,4,5-(MeO)(3)C6H2, 4-FC6H4, 4-Me2NC6H4) was synthesized and characterized by electron paramagnetic resonance. Three structures were determined by X-ray diffraction analysis and revealed the expected bent metallocene structure with two cyclopentadienyl ligands and two chlorides coordinated to niobium in the oxidation state IV. Chlorides and the centroids of the (5)-bonded cyclopentadienyl rings define a distorted tetrahedron. The cytotoxicity study has demonstrated that substitution with methoxybenzyl groups can lead to highly active species, but the activity strongly varies with the number and positions of the methoxy groups in the benzene ring. The most active species under study - {2,4-(MeO)(2)C6H3CH2C5H4}(2)NbCl2 - has a maximal inhibitory concentration value comparable with cisplatin. metallocene dihalides; cytotoxicity; EPR spectroscopy; X-ray diffraction analysis; leukemia therapy

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