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Green Electrochemical Sensors Based on Boron Doped Diamond and Silver Amalgam for Sensitive Voltammetric Determination of Antineoplastic Agent Methotrexate
Authors: Šelešovská Renáta | Bandžuchová Lenka | Chalupník Miroslav
Year: 2014
Type of publication: ostatní - článek ve sborníku
Name of source: 47th Heyrovsky discussion on electrochemistry of organic and bioactive compounds
Publisher name: Ústav fyzikální chemie Jaroslava Heyrovského AV ČR
Place: Praha
Page from-to: 54
Titles:
Language Name Abstract Keywords
eng Green Electrochemical Sensors Based on Boron Doped Diamond and Silver Amalgam for Sensitive Voltammetric Determination of Antineoplastic Agent Methotrexate Methotrexate (MTX) is an antimetabolite and antifolate drug used in treatment of cancer and autoimmune diseases. It acts by inhibiting the metabolism of folic acid. Methotrexate was originally used as part of combination chemotherapy regimens to treat many kinds of cancers. It is still the mainstay for the treatment of many neoplastic disorders including acute lymphoblastic leukaemia. The structure of MTX is analogous to folic acid, it differs only in a methyl group connected to the amino group of amino benzoic acid (N(10)) and the amino group which is substituted on C4 on pyridine circle. The voltammetric behavior of methotrexate using unmodified boron-doped diamond electrode (BDDE) [1], mercury meniscus modified (m-AgSAE) and polished silver solid amalgam electrode (p-AgSAE) [2] is described in present paper. Optimum working conditions for differential pulse voltammetric determination of MTX were found and proposed sensitive methods were employed in the analyses of pharmaceutical preparations. Voltammetry; Boron-doped diamond electrode; Antineoplastic agent; Methotrexate