University of PardubiceFaculty of Chemical Technology

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Inflammatory response to coronary stent implantation and its association with red blood cell membrane fatty acids

Authors: Mužáková Vladimíra | Skalický Jiří | Čermák Tomáš | Matějka Jan | Kovařík Jakub | Laštovička Petr | Čegan Alexander

Year: 2014

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Inflammatory response to coronary stent implantation and its association with red blood cell membrane fatty acids	In coronary heart disease (CHD), treatment of significant stenosis by percutaneous coronary intervention (PCI) with stent implantation elicits local and systemic inflammatory responses. Their intensity and magnitude negatively affect clinical outcome and increase risk of stent restenosis. This study was aimed to description of inflammatory response and elucidation whether red blood cell (RBC) membrane fatty acid profile influences inflammation after PCI. Blood samples of patients with CHD undergoing PCI were analyzed before, 24 and 48 h after stent implantation (n=24). High sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6), serum amyloid A (SAA) were determined by standard procedures. RBC membrane fatty acid profiles were measured by GC/FID. Patients after PCI exhibited significant increase of inflammatory markers. The earliest response, with maximum after 24 h, was observed in case of IL-6 (1.0 ± 2.1 ng/l , 24 h: 7.4 ± 4.7 ng/l , 48 h: 4.4 ± 4.7 ng/l), followed by elevation of hs-CRP as well as SAA, with maxima after 48 h. Considering RBC membrane fatty acids, statistically significant (p<0.05) positive association with hsCRP baseline was found for myristic acid (r=0.65), 14-methylhexadecanoic acid (r=0.54) and trans-palmitoleic acid (r=0.58), inverse association with magnitude of change in CRP was indicated for oleic acid (r=-0.46). In case of SAA, 12-methyltetradecanoic acid (r=0.51) was positively related, as well as arachidic acid (r=0.52), lignoceric (r=0.59) and gama-linolenic acid (r=0.52) were significantly positively correlated with postprocedural increase in IL-6. Inflammatory response after PCI includes the rapid increase in IL-6 (maximum after 24 h), while peaks in CRP and SAA culminate after 48 h. Positive correlation with postprocedural increase of inflammatory markers was found for linoleic and gama-linolenic acid, precursors of proinflammatory n-6 PUFA, and branched-chain and very-long-chain fatty acids.	Inflammatory response; coronary stent implantation; red blood cell membrane fatty acids