Publication detail

PREANALYTIC PHASE OPTIMIZATION OF ETHYL FERULATE ANALYSIS AFTER PENETRATION EXPERIMENTS INTO THE SKIN WITHIN VARIOUS DELIVERY SYSTEMS

Authors: Svoboda Marek | Salvetova Eva | Smejkalova Daniela | Muthny Tomas

Year: 2014

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	PREANALYTIC PHASE OPTIMIZATION OF ETHYL FERULATE ANALYSIS AFTER PENETRATION EXPERIMENTS INTO THE SKIN WITHIN VARIOUS DELIVERY SYSTEMS	This study deals with optimization of ethyl ferulate (EF) after skin penetration tests. The skin is known to be difficult biological matrix to deal with. Therefore, sample preparation was crucial part in this case. We found that EF has been degraded during skin penetration tests which was most likely due to resident bacterial microflora. Optimization of antimicrobial content and extraction point solved low recovery values. Furthermore, we confirmed that polymeric micelles based on hyaluronic acid improved penetration abilities of EF.	Ethyl ferulate, skin penetration, HPLC

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