Publication detail

Percutaneous delivery of ethylferulate in HA based polymeric micelles

Authors: Svoboda Marek | Salvetova Eva | Smejkalova Daniela | Muthny Tomas

Year: 2014

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Percutaneous delivery of ethylferulate in HA based polymeric micelles	Objective: Ethylferulate (EF), an ester of ferulic acid, is a skin soothing agent which has powerful radical scavenging and UV absorption properties. It is intended for use in cosmetics in the treatment of premature skin aging and UV-radiation induced burns. Despite of these beneficial properties, the disadvantage of this compound is the hydrophobic character which can bring along various limits. Use of appropriate delivery system can improve its penetration properties as well as its incorporation into cosmetic formulations. The aim of our study was to evaluate and compare percutaneous delivery of pure EF (EF-P) and EF joined to hydrophilic delivery system (EF-DS) formed of polymeric micelles which are based on hyaluronic acid (HA). Methodology: Penetration experiments with excised and dermatomed porcine ear skin were done using Franz-type diffusion cells for 24 hours. Caffeine, as penetration reference compound, was used. EF and Caffeine were assessed by HPLC-UV/VIS. Results: It was found that polymeric micelles increased the penetration of EF into the stratum corneum, epidermis and dermis 24-h post-application in comparison to pure EF. Conclusion: The results indicate that hyaluronic acid based polymeric micelles are suitable carriers for EF.	Ethylferulate, skin penetration, polymeric micelles, hyaluronic acid

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