Publication detail

Comparison of inhibitory effects between acetaminophen-glutathione conjugate and reduced glutathione in human glutathione reductase

Year: 2014

Type of publication: článek v odborném periodiku

Name of source: Journal of Applied Toxicology

Publisher name: Wiley-Blackwell

Page from-to: 968-973

Titles:

Language	Name	Abstract	Keywords
cze	Srovnání inhibice mezi konjugátem acetaminofenu a glutathionu u lidské glutathionreduktasy	Acetaminofenové poškození je častou příčinou jaterního selhání, a proto jsme se zaměřili na srovnání inhibice mezi konjugátem acetaminofenu a glutathionu u lidské glutathionreduktasy.	acetaminofenová toxicita; glutathion; glutathionreduktasa.
eng	Comparison of inhibitory effects between acetaminophen-glutathione conjugate and reduced glutathione in human glutathione reductase	Acetaminophen overdose is the most frequent cause of acute liver injury. The main mechanism of acetaminophen toxicity has been attributed to oxidation of acetaminophen. The type of enzyme inhibition was observed to be competitive in the cases of both APAP-SG and glutathione. As glutathione inhibits GR activity in cells under physiological conditions, the rate of enzyme inhibition ought to be weaker in the case of glutathione depletion that is typical of acetaminophen overdose. Notably, however, enzyme activity likely remains inhibited due to the presence of APAP-SG, which might enhance the pro-oxidative status in the cell.	acetaminophen toxicity; glutathione; glutathione reductase

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