Publication detail

Acetaminophen toxicity – estimation of a new possible mechanism of cell impairment

Authors: Roušar Tomáš | Vrbová Martina | Roušarová Erika | Červinková Zuzana | Česla Petr

Year: 2014

Type of publication: ostatní - přednáška nebo poster

Name of source: Toxicology Letters

Publisher name: Elsevier Ireland Ltd

Place: Shannon

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Acetaminophen toxicity – estimation of a new possible mechanism of cell impairment	Acetaminophen is a safe drug at therapeutic doses. However, after overdose, it can cause cell impairment that may lead even to acute liver or kidney failure. Although the toxic mechanism has been studied for 40 years, some principles of toxicity remain unknown. In addition, a number of clinical studies focused on occurrence of acetaminophen toxicity at therapeutic doses have been published and some rather unexplainable reports from animal studies have appeared as well. Therefore, it is obvious that some parts contributing acetaminophen toxicity likely remain to be found.	Acetaminophen toxicity; glutathione; ROS

Search