University of PardubiceFaculty of Chemical Technology

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Antimicrobial activity of selected natural compounds against multi-resistant pathogens

Authors: Kukla Rudolf | Mazurová Jaroslava | Slehová Eva | Sleha Radek | Jantovská Alexandra | Kopáčová Lucie

Year: 2014

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

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Language	Name	Abstract	Keywords
eng	Antimicrobial activity of selected natural compounds against multi-resistant pathogens	Background and aims The increasing number of microorganisms resistant to antimicrobial agents has been global challenge due to the high selective antibiotic pressure. Multi-resistant pathogens such as Staphylococcus aureus, Enterococcus faecium, Pseudomonas aeruginosa and Klebsiella pneumoniae may cause serious disorders of children including skin infections. One of possible approaches for skin infections treatment is to exploit antimicrobial properties of natural compounds instead of antibiotics. Aim of this study was to evaluate an antimicrobial activity of selected natural compounds against Staphylococcus aureus, Enterococcus faecium, Pseudomonas aeruginosa and Klebsiella pneumoniae strains. Methods Antimicrobial properties of natural substances including thymol, carvacrol, eugenol, gallic acid, alfa-pinen, beta-pinen and usnic acid against tested microorganisms were determined as minimum inhibitory concentration (MIC) using a microdilution method. The MIC value was defined as the lowest concentration of natural compound in which the growth of microorganisms was inhibited. Results We found usnic acid to be the most effective against gram-positive bacteria. MIC values were in range 4.7-18.8 mg/l. However, thymol and carvacrol were substances with broad spectrum of efficacy against all tested microorganisms; MIC values were in range 300 600 mg/l and 150-1200 mg/l, respectively. Gallic acid was the most efficient against Pseudomonas aeruginosa strains; MIC values were in range 150-300 mg/l. Conclusions Our results revealed natural compounds to possess broad spectrum of activity against examined microorganisms. The present study describes antimicrobial properties of selected natural compounds and points out their possible involvement in the therapy of skin infections.	Antimicrobial; activity; selected; natural; compounds; against; multi-resistant; pathogens