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Degradation study of nitroaromatic explosives 2-diazo-4,6-dinitrophenol and picramic acid using HPLC and UHPLC-ESI-MS/MS
Authors: Matyáš Robert | Havlíková Lucie | Ihnát Likáš | Nováková Lucie | Šatínský Dalibor
Year: 2014
Type of publication: článek v odborném periodiku
Name of source: Analytical Methods
Publisher name: Royal Society of Chemistry
Place: Cambridge
Page from-to: 4761-4768
Titles:
Language Name Abstract Keywords
cze Studie rozkladu 2-diazo-4,6-dinitrofenolu a kyseliny pikraminové s použitím metod HPLC a UHPLC-ESI-MS/MS Pro stanovení diazodinitrofenolu (DDNP) a její výchozí látky kyseliny pikraminové byla vyvinuta metoda kapalinové chromatografie s UV detekcí. Zároveň byl zkoumán vliv tepelné expozice, fotolýzy, hydrolýzy a oxidace DDNP. DDNP je stabilní v kyselém i bazickém prostředí. Rozklad DDNP byl zaznamenán při jeho expozici při 50°C po dobu 24 hodin, při fotolýze UV zářením a při oxidaci peroxidem vodíku. Během rozkladu DDNP byly identifikovány jeho rozkladné produkty. Třaskavina; stříbrná sůl 4,6-diazido-N-nitro-1,3,5-triazin-2-aminu; AgDANT; 4,6-diazido-N-nitro-1,3,5-triazin-2-amin; náhrada azidu olovnatého
eng Degradation study of nitroaromatic explosives 2-diazo-4,6-dinitrophenol and picramic acid using HPLC and UHPLC-ESI-MS/MS A new and fast HPLC method with UV detection was developed and validated for the simultaneous determination of nitroaromatic explosives diazodinitrophenol (DDNP), the raw material picramic acid (PicA) and three degradation products of DDNP. DDNP and PicA were subjected to forced degradation. DDNP was found to be stable under acidic and basic conditions, while thermal, oxidative and photolytic decomposition resulted in three degradation products. Degradation products were separated from DDNP using Ascentis® Express C18 fused core particle column and subsequently characterised using UHPLC-ESI-MS/MS method. Optimal chromatography was performed using the isocratic elution of mobile phase consisting of acetonitrile–orthophosphoric acid 0.085% 30 : 70 (v/v) pumped at a flow rate of 0.8 mL/min at a temperature of 50°C. System suitability test parameters, linearity and precision of the HPLC method were evaluated. The new HPLC method is suitable for a fast determination of DDNP and degradation products in various samples. Our work provides a basic view on the stability and aspects of degradation process of nitroaromatics DDNP and PicA, and shows the formation of degradation products. Primary explosive; silver salt of 4,6-diazido-N-nitro-1,3,5-triazine-2-amine; AgDANT; 4,6-diazido-N-nitro-1,3,5-triazine-2-amine; lead azide replacement

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