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Sensitive determination of anti-inflammatory drug sulfasalazine using green electrochemical sensor based on silver solid amalgam
Authors: Janíková Lenka | Šelešovská Renáta | Štěpánková Michaela | Chýlková Jaromíra
Year: 2015
Type of publication: ostatní - článek ve sborníku
Name of source: Chemistry and Life 2015: Book of Abstracts
Publisher name: Vysoké učení technické v Brně
Place: Brno
Page from-to: 91
Titles:
Language Name Abstract Keywords
eng Sensitive determination of anti-inflammatory drug sulfasalazine using green electrochemical sensor based on silver solid amalgam Sulfasalazine (SSZ) belongs to the aminosalycilate group of pharmaceuticals and is primarily applied for treatment of inflammatory bowel diseases, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and juvenile rheumatoid arthritis [1]. Electrochemical methods represent very good alternative to time and money consuming analytical techniques like liquid chromatography, which are commonly used for sensitive determination of pharmaceuticals [2]. The presented voltammetric method, which employed non-toxic silver solid amalgam [3,4] as a material of working electrode, citrate buffer of pH 5 as a supporting electrolyte, and adsorptive stripping square wave voltammetry (AdS SWV) as a measuring technique, proved excellent results like high repeatability (RSD of 15 repeated measurements of 2.50×10−7 mol L−1 was 2.79 %), good repeatability of repeated determination of various SSZ concentration levels (RSD(5) ≤ 5.33 %), wide linear dynamic range (5×10−9 ‒ 4×10−6 mol L−1) and low limit of detection (LOD = 3.24×10−9 mol L−1), which confirms high sensitivity of the proposed method. Moreover, the proposed method was successfully applied for voltammetric determination of SSZ in the sample of pharmaceutical preparation. Finally, it can be concluded, that silver solid amalgam electrode in combination with AdS SWV represents sensitive tool for determination of SSZ. sulfasalazine; voltammetry; silver solid amalgam electrode; determination

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