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Bioinorganic chemistry of vanadocene dichloride

Authors: Honzíček Jan | Vinklárek Jaromír

Year: 2015

Type of publication: článek v odborném periodiku

Name of source: Inorganica Chimica Acta

Page from-to: 87-94

Titles:

Language	Name	Abstract	Keywords
cze	Bioanorganická chemie vanadocen dichloridu	Tento souhrný článek sumarizuje vývoj bionaorganické chemie vanadocen dichloridu a jeho derivátů. Zaměřuje se především na studie související s biologickou aktivitou, které byly publikovány v uplynulých čtyřech desetiletích.	vanadocen dichlorid; protinádorová aktivita; spermicidní aktivita
eng	Bioinorganic chemistry of vanadocene dichloride	This review article summarizes the development in bioinorganic chemistry of vanadocene dichloride and its derivatives. It is focused mainly on studies related with biological activity appearing in past four decades, after the antitumor activity of bent metallocenes was discovered by Petra Kopf-Maier and Hartmut Kopf. The first part deals with the unique hydrolytic chemistry of vanadocene dichloride and the reactivity with biologically relevant molecules, necessary for understanding of its antitumor effect on the molecular level. The second part summarizes the results of in vitro and in vivo biological assays. It covers not only the experiments related with antitumor activity but also a series of studies focused on the spermicidal properties with unique mechanism of action. A special attention is given to structure-activity studies on modified vanadocene compounds.	Vanadocene dichloride; Antitumor activity; Spermicidal activity; Structure-activity relationship