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Synthesis, characterization and cytotoxic effect of vanadocene complexes bearing substituted 2,2 '-bipyridines and 4,5-diazafluoren-9-one
Authors: Šebestová Lucie | Vinklárek Jaromír | Honzíček Jan | Růžičková Zdeňka | Řezáčová Martina
Year: 2015
Type of publication: článek v odborném periodiku
Name of source: Inorganica Chimica Acta
Publisher name: Elsevier Science SA
Place: Lausanne
Page from-to: 211-218
Titles:
Language Name Abstract Keywords
cze Příprava, charakterizace a cytotoxicita vanadocenových komplexů se substituovanými 2,2 '-bipyridiny a 4,5-diazafluoren-9-ononem Tato studie popisuje přípravu vanadocenových komplexů typu [Cp'2V(L)][OTf](2), kde Cp je substituovaný cyklopentadienylový kruh a L je N,N-chelatující ligand. metallocen; vanad; N,N-chelatující ligand; EPR spektroskopie; cytotoxicita
eng Synthesis, characterization and cytotoxic effect of vanadocene complexes bearing substituted 2,2 '-bipyridines and 4,5-diazafluoren-9-one This study describes the synthesis of vanadocene compounds [Cp'2V(L)][OTf](2), where Cp' is substituted cyclopentadienyl ring and L is N,N-chelating ligand. All prepared compounds were characterized by analytical and spectroscopic methods. The structures of [(eta(5)-C5H4Me)(2)V(bpy)][OTf](2), [(eta(5)-(C5H4Pr)-Pr-i)(2)V(bpy)][OTf](2)center dot CH2Cl2, [Cp2V(4,4'-Me-2-bpy)][OTf](2), [Cp2V{4,4'-(MeO)(2)-bpy}][OTf](2)center dot MeOH and [(eta(5)-C5H4 Me)(2)V(dafone)][OTf](2) were further confirmed by the X-ray diffraction analysis. The cytotoxicity study, performed on human leukemia cells MOLT-4 and HL-60, demonstrates that the activity of the vanadocene complexes strongly depends on the nature of the coordinated chelating ligand. The high cytotoxicity was observed for the complex bearing 2,2'-bipyridine, [(eta(5)-C5H4Me)(2)V(bpy)][OTf](2), that shows IC50 values close to the data observed for cisplatin. Metallocene; Vanadium; N,N-Chelating ligands; EPR spectroscopy; Cytotoxicity

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