University of PardubiceFaculty of Chemical Technology

University

Employees
|
Students
Česky

Publication detail

Lipidomic analysis of breast cancer samples using LC/MS

Authors: Cífková Eva | Lísa Miroslav | Hrstka R | Vrána D | Gatěk J | Melichar B | Vojtěšek B | Holčapek Michal

Year: 2015

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Lipidomic analysis of breast cancer samples using LC/MS	Breast cancer is the most common malignant tumor in women population and one of the most common causes of cancer death. The lipid metabolism plays an important role in the oxidative stress and is associated with factors linked to the breast cancer risk including the hormonal balance, body mass index, breast density, drug metabolism, growth of insulin levels, etc. The coupling of liquid chromatography and mass spectrometry (LC/MS) is the technique most frequently used for lipidomic analysis of various biological samples. The LC/MS characterization of lipid differences between normal and cancer cell lines and human tissues is the first step for the identification of the statistically significant lipids in observed type of cancer.