Publication detail

Characterization of Acetaminophen Toxicity in Human Kidney HK-2 Cells

Authors: Hauschke Martina | Roušarová Erika | Česla Petr | Brůčková Lenka | Roušar Tomáš

Year: 2016

Type of publication: článek v odborném periodiku

Name of source: Physiological Research

Publisher name: Fyziologický ústav AV ČR

Place: Praha

Page from-to: 627-635

Titles:

Language	Name	Abstract	Keywords
cze	Charakterizace acetaminofenové nefrotoxicity u HK-2 buněk	Ledviny jsou orgánem, který je velmi často vystaven účinku toxinů díky metabolickému obratu, za nějž ledvinná tkán zodpovídá.	Renální buněčné kultury; in vitro testy
eng	Characterization of Acetaminophen Toxicity in Human Kidney HK-2 Cells	Acetaminophen (APAP) overdose causes liver injury, but in some cases it is associated also with renal impairment. While several studies exist in relation to acetaminophen nephrotoxicity, no reports have been published describing intracellular changes related to APAP nephrotoxicity in vitro. Because proximal tubular cells are considered to constitute a secondary site of druginduced injury after hepatocytes, our study's aim was to estimate the toxicity in the human HK-2 cell line.	Renal cell lines; in vitro tests

Search