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SYNTHESIS OF SUBSTITUTED 6-FLUOROBENZOTHIAZOLE AMIDES AS POTENTIAL ANTIMICROBIAL AGENS

Authors: Pejchalová Marcela | Pejchal Vladimír | Růžičková Zdeňka

Year: 2016

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	SYNTHESIS OF SUBSTITUTED 6-FLUOROBENZOTHIAZOLE AMIDES AS POTENTIAL ANTIMICROBIAL AGENS	A series of novel 1-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-3-substituted phenyl amides was synthesized by was simple and technologically applicable condensation reaction of (1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethanamine with substituted benzoyl chlorides under mild conditions.All the compounds have been screened for antibacterial and antifungal activities using two fold serial dilution method. Chloramphenicol, cefoperazone and amphotericin B were used as comparative standard drugs. All compounds were screened for antibacterial activity against gram-positive bacterial strains S. aureus, S. epidermidis, E. faecalis and gram-negative bacterial strains E. coli, E. cloacae, P. mirabilis, P. aeruginosa in Mueller-Hinton agar medium and for antifungal activity against C. albicans, C. glabrata and C. tropicalis in Sabouraud’s dextrose agar. C. albicans as an opportunistic pathogen representing a serious threat to immunocompromised individuals deserves a special focus along with other fungi strains under investigation. As the number of immunologically weakened patients increase, opportunistic infections have become a widely recognized public health problem. In that respect, 13 exhibited comparable antifungal activity against C. albicans and C. tropicalis when amphotericin B is taken as a standard drug in use. Compounds 4 and 8 were selectively active against C. glabrata and C. albicans respectively.	SYNTHESIS SUBSTITUTED 6-FLUOROBENZOTHIAZOLE; AMIDES; ANTIMICROBIAL; AGENS